2001～2015年深圳市儿童肿瘤的发病特征和时间趋势

Incidence and Trends of Childhood Cancer in Shenzhen,2001～2015

[目的]探讨2001～2015年深圳市儿童恶性肿瘤的流行特征和发病趋势,为制定深圳市儿童恶性肿瘤防治政策提供基础数据。[方法]根据深圳市肿瘤发病登记处收集的2001～2015年儿童恶性肿瘤发病数据和相应年份的人口资料,计算儿童恶性肿瘤发病粗率,以及标准化人口年龄调整的发病率(中国人口标化率和世界人口标化率),利用Joinpoint软件进行趋势分析。[结果] 2001～2015年深圳市肿瘤登记处共登记儿童恶性肿瘤1068例,粗发病率为15.96/10万,中标率为15.42/10万,世标率为16.10/10万。男童发病率明显高于女童,男女发病性别比为1.25∶1。发病率前3位依次为白血病(7.07/10万)、脑/神经系统肿瘤(2.43/10万)和恶性淋巴瘤(1.21/10万)。从时间趋势上看,儿童恶性肿瘤发病率无明显变化,世标率APC为2.00%(Z=1.9,P=0.1),仅男童恶性肿瘤发病率略微上升,APC为3.38%(Z=2.7,P<0.01);不同肿瘤(白血病、脑/神经系统肿瘤和恶性淋巴瘤)发病率也无明显改变。[结论]深圳市儿童恶性肿瘤发病率处于较高水平,需采取综合措施进行预防和控制。

[Purpose]To analyze the incidence and epidemiologic trends of childhood cancer in Shenzhen during 2001 to 2015.[Methods]The childhood cancer incidence data and population data were collected from Shenzhen Cancer Registry.The crude incidence,age-standardized incidence by Chinese standard population(ASR China)and age-standardized incidence by world standard population(ASR world)were calculated.The annual percentage change(APC)of the incidence was analyzed by Joinpoint regression.[Results]Total 1068 new cases of childhood cancer were registered in Shenzhen Cancer Registry from 2001 to 2015.The crude incidence was 15.96/10~5,with ASR China of 15.59/10~5 and ASR world of 16.10/10~5.The incidence of boys was higher than that of girls,with a sex ratio of 1.25∶1.The top three cancer types were leukemia(7.07/10~5),central nervous system tumors(2.43/10~5)and lymphomas(1.21/10~5).In terms of time trend,the incidence of childhood cancer had no significant increase of APC(APC=2.00%,Z=1.9,P=0.1),but incidence of the boys had been increasing slightly(APC=3.38%,Z=2.7,P<0.01).The incidence of leukemia,central nervous system tumors and lymphomas were stable during 2001 to 2015.[Conclusion]The incidence of childhood is relatively high in Shenzhen,but the time trends are relatively stable during 2001 to 2015.