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肠外营养相关性肝损害及其防治 被引量：11

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摘要 肠外营养(parenteral nutrition,PN)能明显改善危重病患者的营养状态,提高患者生存率,但长期PN后往往伴随感染、胆汁淤积、肝功能异常、肝脏脂肪浸润、肝脏纤维化甚至肝硬化,以上现象通常被称为'肠外营养相关性肝损害(parenteral nutrition-associated liver disease,
作者 张有成 马玉靖 耿婕
机构地区 兰州大学第二医院普通外科
出处 《中华普通外科学文献（电子版）》 2015年第6期424-427,共4页 Chinese Archives of General Surgery(Electronic Edition)
关键词 肠外营养 肝损害 PARENTERAL 危重病患者 肝脏纤维化 nutrition 肝脏脂肪浸润 肠衰竭 植物甾醇 脂质过氧化
分类号 R459.3 [医药卫生—治疗学] R575 [医药卫生—消化系统]
  • 相关文献

参考文献19

  • 1Zaloga GP.Phytosterols,Lipid Administration,and Liver Disease During Parenteral Nutrition. Journal of Parenteral and Enteral Nutrition . 2015
  • 2Calkins K L,Havranek T,Kelley-Quon LI,et al.Low-dose parenteral soybean oil for the prevention of parenteral nutrition-associated liver disease in neonates with gastrointestinal disorders:a multicenter randomized controlled pilot study. Journal of Parenteral and Enteral Nutrition . 2015
  • 3Bharadwaj S,Gohel T,Deen OJ,et al.Fish oil-based lipid emulsion:current updates on a promising novel therapy for the management of parenteral nutrition-associated liver disease. Gastroenterol Rep . 2015
  • 4Pastor-Clerigues A,Marti-Bonmati E,Milara J,et al.Anti-inflammatory and anti-fibrotic profile of fish oil emulsions used in parenteral nutrition-associated liver disease. Plos One . 2014
  • 5Vlaardingerbroek H,Ng K,Stroll B,et al.New generation lipid emulsions prevent PNALD in chronic parenterally fed preterm pigs. Journal of Lipid Research . 2014
  • 6Turner JM,Josephson J,Field CJ,et al.Liver disease,systemic inflammation,and growth using a mixed parenteral lipid emulsion,containing soybean oil,fish oil,and medium chain triglycerides,compared with soybean oil in parenteral nutrition-fed neonatal piglets. Journal of Parenteral and Enteral Nutrition . 2015
  • 7Lim DW,Wales PW,Josephson JK,et al.Glucagon-like peptide2 improves cholestasis in parenteral nutrition-associated liver disease. Journal of Parenteral and Enteral Nutrition . 2014
  • 8Wales PW,Allen N,Worthington P,et al.A.S.P.E.N.Clinical Guidelines:Support of Pediatric Patients With Intestinal Failure at Risk of Parenteral Nutrition-Associated Liver Disease. Journal of Parenteral and Enteral Nutrition . 2014
  • 9Ng K,Stoll B,Chacko S,et al.Vitamin E in New-Generation Lipid Emulsions Protects Against Parenteral Nutrition-Associated Liver Disease in Parenteral Nutrition-Fed Preterm Pigs. Journal of Parenteral and Enteral Nutrition . 2015
  • 10Gertrud Angsten,Yigael Finkel,Steven Lucas.Improved Outcome in Neonatal Short Bowel Syndrome Using Parenteral Fish Oil in Combination With omega-6/9 Lipid Emulsions. JOURNAL OF PARENTERAL AND ENTERAL NUTRITION . 2012

二级参考文献22

  • 1吴江,徐远飞,蔡威,汤庆娅,冯一,陶晔璇,施诚仁.谷氨酰胺预防幼兔全肠外营养相关肝损害的实验研究[J].外科理论与实践,2004,9(5):393-396. 被引量：1
  • 2刘红,刘建.熊脱氧胆酸治疗妊娠期肝内胆汁淤积症护肝机制的研究进展[J].重庆医学,2005,34(1):141-142. 被引量：11
  • 3张澜,曹云.新生儿胃肠外营养相关性肝胆并发症研究进展[J].国外医学（儿科学分册）,2005,32(3):185-187. 被引量：18
  • 4蔡威,汤庆娅,陶晔璇,冯一.中国新生儿营养支持临床应用指南[J].中华儿科杂志,2006,44(9):711-714. 被引量：210
  • 5Al-Hathlol K,Al-Madani A,Al-Saif S,et al.Ursodeoxycholic acid therapy for intractable total parenteral nutrition-associated cholestasis in surgical very low birth weight infants[J].Singapore Med J,2006,47(2):147-51.
  • 6Hsieh MH,Pai W,Tseng HI,et al.Parenteral nutrition-associated cholestasis in premature babies:risk factors and predictors[J].Pediatr Neonatol,2009,50(5):202-207.
  • 7Willis TC,Carter BA,Rogers SP,et al.High rates of mortality and morbidity occur in infants with parenteral nutrition-associated cholestasis[J].JPEN J Parenter Enteral Nutr,2010,34(1):32-37.
  • 8Chen CY,Tsao PN,Chen HL,et al.Ursodeoxycholic acid(UDCA)therapy in very-low-birth-weight infants with parenteral nutrition-associated cholestasis[J].J Pediatr,2004,145(3):317-321.
  • 9Dickerson,Roland N,Karwoski,et al.Endotoxin-mediated hepatic lipid accumulation during parenteral nutrition in rats.J Am Coll Nutr,2002,21:351-356.
  • 10Lievin V,Peiffer I,Hudault S,et al.Bifidobacterium strains from resident infant human gastrointestinal microflora exert antimicro bial activity.Gut,2000,47:646-652.

共引文献19

同被引文献71

引证文献11

二级引证文献29

中华普通外科学文献（电子版）
2015年 第6期

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