摘要
新生血管化在创面愈合和组织再生过程中有着重要的作用,它提供组织修复必须依赖的物质基础(氧气、营养物质等)。随着近年来分子生物学技术和细胞工程技术的发展,干细胞技术和目的基因转染在创面愈合和血管生成方面展现独特的优势。文章总结了创面愈合的过程,慢性创面难愈的部分原因,血管新生在慢性创面愈合过程中的作用,相关生长因子基因转染技术、效率及与转基因干细胞的联合应用在慢性创面愈合过程中血管新生中的新发现,为临床上治疗慢性创面等棘手问题提供参考。
Objective Neovascularization plays a critical role in wound healing and regeneration,which provides material basis,such as oxygen,nutrients for tissue repair. With the developement of molecular biology and cell engineering technology,gene transfection and stem cell technique show unique advantages in the wound repair and angiogenesis. This paper reviewed the process of wound healing and reasons of refractory chronic wounds,the role of the relevant growth factor gene transfection technology and its efficiency,the combination of genetically modified stem cells in chronic wound healing process which provided reference for clinical treatment of chronic wounds and other thorny issues.
出处
《中华损伤与修复杂志（电子版）》
CAS
2015年第6期531-534,共4页
Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)
基金
国家自然基金项目(81272081)
关键词
伤口愈合
新生血管化
病理性
转基因
干细胞
Wound healing
Neovascularization,pathologic
Transgenes
Stem cells
