硫化氢调控微小核糖核酸对内质网应激影响的研究进展

Advances in studies on the effect of hydrogen sulfide regulating microRNA on endoplasmic reticulum stress

内质网应激(ERS)与细胞凋亡存在着密切联系,而硫化氢对ERS的影响,可以减轻器官受损后的损伤程度,减缓相应器官的细胞凋亡,对机体起到一定的保护作用。硫化氢可以调控微小核糖核酸(miRNA)的表达,而miRNA可以阻止信使核糖核酸(mRNA)所翻译蛋白质的表达,其中也包括参与ERS的蛋白质,这些蛋白质在细胞ERS发生至细胞凋亡的过程中起着至关重要的作用。总得来说,硫化氢对miRNA的表达调控可影响细胞内相应蛋白质的表达,进而影响细胞内ERS水平,从而发挥对机体的保护作用。本文通过对比国内外相关研究,分别从内质网与ERS、硫化氢与miRNA、miRNA与ERS、硫化氢与ERS 4个方面,就硫化氢通过调控miRNA表达进而影响ERS进行综述,归纳其作用机制,为硫化氢对ERS影响的进一步研究提供理论基础。

Endoplasmic reticulum stress(ERS)is closely related to apoptosis,and the effect of hydrogen sulfide on ERS can reduce the degree of damage after organ damage,slow down the apoptosis of the corresponding organs,play a certain protective role on the body.Hydrogen sulfide can regulate the expression of microRNA(miRNA),which can block the expression of target messenger RNA(mRNA)-translated proteins,including proteins involved in ERS,which play a crucial role in the progression of ERS to apoptosis.In general,the regulation of the expression of miRNA by hydrogen sulfide can affect the expression of corresponding proteins in cells,thereby affecting the level of ERS in cells,so as to exert a protective effect on the body.This paper summarizes the influence of hydrogen sulfide on ERS through regulating the expression of miRNA by comparing the relevant studies at home and abroad,hydrogen sulfide and miRNA,miRNA and ERS,hydrogen sulfide and ERS respectively,and summarizes its mechanism,providing a theoretical basis for further research on the influence of hydrogen sulfide on ERS.