浅谈在糖尿病性视网膜病变中调节血管内皮生长因子产生的信号通路

Exploring the signal pathway regulating vascular endothelial growth factor production in diabetic retinopathy

糖尿病性视网膜病变(DR)作为糖尿病(DM)在眼部最严重的微血管并发症,已成为全球工作年龄人群首位的致盲性眼病。血管内皮生长因子(VEGF)已被证实在DR新生血管的形成中起着重要作用,VEGF的表达增加可导致新生血管形成、血管内皮细胞通透性增加、促凋亡蛋白抑制作用减弱以及各种其它炎症介质的激活等病理改变的发生。因此,探索各种调节VEGF产生的信号通路有助于更深层次的了解这些病理改变发展的关系。本文中笔者就DR中各种调节VEGF产生的信号通路以及其与DR的相关性进行综述。

Diabetic retinopathy(DR),as the most serious microvascular complication of diabetes mellitus(DM) in the eye,has become the leading cause of blindness in working-age adults worldwide.Vascular endothelial growth factor(VEGF) has been shown to play an important role in the formation of neovascularization in DR. Increased expression of VEGF leads to pathological changes such as neovascularization, increased vascular endothelial cell permeability, decreased pro-apoptotic protein inhibition,and various other inflammatory mediators were activated. Therefore,exploring various signaling pathways that regulate VEGF production contributes to a deeper understanding of the relationship between these pathological changes. This article reviews the various signaling pathways in DR that regulate VEGF production and their association with DR.