头孢哌酮/舒巴坦治疗慢性心衰并肺部感染的疗效

Efficacy of cefoperazone-sulbactam in treatment of chronic heart failure patients complicated with pulmonary infection

目的探讨慢性心衰并肺部感染患者给予头孢哌酮/舒巴坦治疗的疗效。方法随机选取2015年5月-2017年5月医院收治的慢性心衰并肺部感染患者60例,依据治疗方法分为头孢哌酮/舒巴坦组(n=30)和头孢曲松钠组(n=30)两组,对两组患者的临床疗效、菌株分离及完全清除情况、退热时间、咳嗽消失时间、喘息消失时间、肺部湿啰音消失时间、住院时间、不良反应发生情况进行统计分析。结果头孢哌酮/舒巴坦组患者治疗的总有效率96.67%(29/30)显著高于头孢曲松钠组73.33%(22/30)(P<0.05),退热时间、咳嗽消失时间、喘息消失时间、肺部湿啰音消失时间、住院时间均显著短于头孢曲松钠组(P<0.05),不良反应发生率3.33%(1/30)显著低于头孢曲松钠组16.67%(5/30)(P<0.05)。头孢哌酮/舒巴坦组分离菌株11株,完全清除10株,完全清除率为90.91%;头孢曲松钠组分离菌株10株,完全清除5株,完全清除率为50.00%。头孢哌酮/舒巴坦组的菌株完全清除率显著高于头孢曲松钠组(P<0.05)。结论慢性心衰并肺部感染患者给予头孢哌酮/舒巴坦治疗的疗效较头孢曲松钠显著。

OBJECTIVE To explore the efficacy of cefoperazone-sulbactam in treatment of chronic heart failure patients complicated with pulmonary infection.METHODS A total of 60 chronic heart failure patients complicated with pulmonary infection who were treated in the hospitlafrom May 2015 to May 201 were randomly enrolled in the study and divided into the cefoperazone-sulbactam group with 30 cases and the ceftriaxone sodium group with30 cases according to the treatment measures.The clinical curative effect,number of isolated strains,completed eradication rate,time of fever abatement,time of disappearance of cough,time of disappearance of wheezing,time of disappearance of pulmonary rales,length of hospital stay and incidence of adverse reactions were statistically analyzed.RESULTS The total effective rates of treatment of the cefoperazone-sulbactam group was 96.67%(29/30),significantly higher than 73.33%(22/30)of the ceftriaxone sodium group(P<0.05).The time of fever abatement,time of disappearance of cough,time of disappearance of wheezing,time of disappearance of pulmonary rales and length of hospital stay were sighificantly shorter in the cefoperazone-sulbactam group than in the ceftriaxone sodium group(P<0.05).The incidence of adverse reactions of the cefoperazone-sulbactam group was 3.33%(1/30),significantly lower than 16.67%(5/30)of the ceftriaxone sodium group(P<0.05).Totally 11 strains were isolated and 10 strains were completely eradicated,with the rate of complete eradication 90.91%;totally 10 strains were isolated and 5 strains were completely eradicated,with the rate of complete eradication50.00%;the rate of complete eradication of the cefoperazone-sulbactam group was significantly higher than that of the ceftriaxone sodium group(P<0.05).CONCLUSION Cefoperzone-sulbactam achieves more remarkable effect on treatment of the chronic heart failure patients complicated with pulmonary infection than ceftriaxone sodium does.