重组人干扰素α-2b联合保妇康栓对HPV感染患者的治疗效果

Effect of recombinant human interferon α-2b combined with Baofukang suppository on treatment of patients with HPV infection

目的探讨重组人干扰素α-2b联合保妇康栓对人乳头瘤病毒(HPV)感染患者的治疗效果。方法选择2017年1月-2017年12月在医院进行治疗的宫颈HPV感染患者180例,按照随机数字的方法将患者分为对照组和观察组,每组均为90例患者,对照组患者给予保妇康栓进行治疗,观察组患者在对照组治疗方法基础上加用重组人干扰素α-2b,对比治疗的效果。结果观察组在治疗后的HPV转阴率高于对照组,差异有统计学意义(P<0.05),观察组治疗效果优于对照组,差异有统计学意义(P<0.05),完成治疗后,两组患者的血清肿瘤坏死因子-α,白细胞介素-6和转化生长因子-β1的浓度均出现了改善,观察组患者改善的幅度大于对照组患者,差异均具有统计学意义(P<0.05),在治疗过程中,两组患者所发生的各类不良反应数据差异均不具有统计学意义。结论使用重组人干扰素α-2b联合保妇康栓对人乳头状瘤病毒(HPV)感染患者进行治疗,可以提高HPV转阴率,提升治疗效果,值得在临床工作中推广。

OBJECTIVE To explore the effect of recombinant human interferonα-2 bcombined with Baofukang suppository on treatment of patients with human papillomavirus(HPV)infection.METHODS A total of 180 patients with cervical HPV infection who were treated in the Second Affiliated Hospital of Hainan Medical University from Jan 2017 to Dec 2017 were enrolled in the study and randomly divided into the control group with 90 cases and the observation group with 90 cases.The control group was treated with Baofukang suppository,while the observation group was treated with additional recombinant human interferonα-2 bon basis of the treatment of the control group,and the curative effects were observed and compared between the two groups.RESULTS The negative rate of HPV of the observation group was sighificantly higher than that of the control group after the treatment(P<0.05),and the curative effect of the observation group was sighificantly better than that of the control group(P<0.05).The levels of serum tumor necrosis factor-α,interleukin-6 and transforming growth factor-β1 of the two groups of patients were improved after the treatment,and the levels of the above indexes were improved more significantly in the observation group than in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups during the treatment(P>0.05).CONCLUSION Recombinant human interferonα-2 bcombined with Baofukang suppository may raise the negative rate of HPV of the patients with HPV infection and improve the curative effect,and it is worthy to be promoted.