乳糖酸阿奇霉素联合莫西沙星对淋球菌感染患者血清IgG和IgM指标的影响

Influence of azithromycin lactose combined with moxifloxacin on serum IgG and IgM of patients with gonococcal infectious gonorrhea

目的研究乳糖酸阿奇霉素配合莫西沙星治疗淋菌感染性淋病的疗效及对血清IgG、IgM指标的影响。方法选取2016年1月-2017年8月在医院接受诊治的88例淋球菌感染患者作为研究对象,将患者按随机数表法分成对照组和研究组,每组44例。对照组患者采用静脉滴注乳糖酸阿奇霉素治疗,研究组患者采用静脉滴注乳糖酸阿奇霉素联合口服莫西沙星治疗,均持续治疗2周。比较两组患者治疗效果、治疗前后血清免疫球蛋白指标变化及不良反应发生情况。结果研究组治疗总有效率90.9%(40/44)高于对照组的72.7%(32/44),差异有统计学意义(P<0.05);治疗后两组患者的免疫球蛋白指标IgG、IgM水平均低于治疗前,且研究组低于对照组(P<0.05);两组患者用药不良反应发生率分别为11.36%(5/44)和9.09%(4/44),两组比较差异无统计学意义。结论乳糖酸阿奇霉素配合莫西沙星治疗淋菌感染性淋病的疗效较好,不良反应少,能有效缓解临床症状及体征,改善机体免疫功能,降低复发风险,值得临床推广。

OBJECTIVE To explore the influence of azithromycin lactose combined with moxifloxacin on serum IgG and IgM of patients with gonococcal infectious gonorrhea.METHODS A total of 88 patients with gonococcal infection who were treated in the hospital from Jan 2016 to Aug 2017 were recruited as the study objects and randomly divided into the control group and the study group,with 44 cases in each group.The control group was given intravenous drip of azithromycin lactose,while the study group was treated with intravenous drip of azithromycin lactose combined with oral administration of moxifloxacin,both groups were treated for 2 consecutive weeks.The curative effects were compared between the two groups of patients,and the levels of serum immunoglobulins and incidence of adverse reactions were observed and compared before and after the treatment.RESULTS The total effective rate of treatment of the study group was 90.9%(40/44),significantly higher than 72.7%(32/44)of the control group(P<0.05).The levels of IgG and IgM of the two groups of patients were significantly lower after the treatment than before the treatment,and the levels of IgG and IgM of the study group were significantly lower than those of the control group(P<0.05).The incidence of drug-induced adverse reactions was 11.36%(5/44)in the study group,9.09%(4/44)in the control group,and there was no significant difference between the two groups.CONCLUSION Azithromycin lactose combined with moxifloxacin can achieve remarkable effect on treatment of the patients with gonococcal infectious gonorrhea,effectively alleviate clinical symptoms and signs,improve the body immune function and reduce the risk of recurrence,with the incidence of adverse reactions low,and it is worthy to be promoted in the hospital.