茵陈蒿汤联合抗感染治疗对肝硬化合并感染患者肝功能及细胞因子的影响分析

Effect of Yinchenhao decoction combined with anti-infection treatment on liver function and cytokines of hepatocirrhosis patients complicated with infection

目的分析茵陈蒿汤联合抗感染治疗对肝硬化合并感染患者肝功能及细胞因子的影响。方法选择2016年3月-2017年3月医院收治的167例肝硬化合并感染患者为研究对象,按照随机数表法,将患者分为对照组83例和试验组84例,对照组患者采用保肝联合抗感染治疗,试验组在对照组的基础上加用茵陈蒿汤。分析茵陈蒿汤联合抗感染治疗对肝硬化合并感染患者肝功能及细胞因子的影响。结果 167例肝硬化合并感染患者,以自发性腹膜炎患者居多,占47.30%(79/167),其次为消化道感染占26.35%(44/167);167例患者共分离病原菌199株,革兰阴性菌142株占71.36%,以大肠埃希菌为主;两组患者治疗前肝功能及细胞因子水平比较差异无统计学意义,治疗后,两组患者指标水平较治疗前均有改善,且试验组的改善效果优于对照组(P<0.05)。结论肝硬化合并感染患者临床上在保肝、抗感染的基础上加用茵陈蒿汤,可以更好地调节细胞因子,改善炎症状态,保护肝功能,提高治疗效果,值得临床推荐使用。

OBJECTIVE To observe the effect of Yinchenhao decoction combined with anti-infection treatment on liver function and cytokines of hepatocirrhosis patients complicated with infection.METHODS A total of 167 hepatocirrhosis patients complicated with infection who were treated in the hosptal from Mar 2016 to Mar 2017 were recruited as the study objects and randomly divided into the control group with 83 cases and the epxerimental group with 84 cases.The contorl gorup was given liver protection treatment combined with anti-infection treatment,while the experimental group was given additional Yinchenhao decoction on basis of the treatment of the contorl group.The effect of Yinchenhao decoction combined with anti-infection treatment on liver function and cytokines of the hepatocirrhosis patients complicated with infection was observed.RESULTS Of the 167 hepatocirrhosis patients complicated with infection,47.30%(79/167)had spontaneous peritonitis,and 26.35%(44/167)had gastrointestinal tract infection.Totally 199 strains of pathogens were isolated from the 167 patients,142(71.36%)of which were gram-negative bacteria.Escherichia coli was the predominant species of the gram-negative bacteria.There were no significant differences in the levels of liver function indexes and cytokines between the two groups of patients before the treatment.The levels of the above indexes were improved in the two groups after the treatment and were improved significantly better in the experimental group than in the control group(P<0.05).CONCLUSION Yinchenhao decoction combined with anti-infection treatment and liver protection treatment may regulate the cytokines,improve the status of inflammation,protect the liver function and raise the curative effect,and it is worthy to be promoted in the hospital.