维生素A对反复呼吸道感染合并贫血患儿的治疗效果

Effect of vitamin A on treatment of recurrent respiratory tract infection children complicated with anemia

目的探讨维生素A治疗反复呼吸道感染合并贫血患儿的临床效果及机制研究。方法选取2013年5月-2017年10月于滨州医学院附属医院进行检查并治疗的反复呼吸道感染合并贫血患儿564例为研究对象,并依据随机数字表法分为试验组和对照组,每组282例。患儿均给予抗感染及其他对症支持疗法,试验组在对照组的基础上辅助维生素A治疗。观察两组患儿的治疗效果,两组患儿炎性因子、免疫球蛋白、T淋巴细胞及贫血相关指标水平变化。结果试验组患儿临床有效率90.07%(254/282)高于对照组的82.27%(232/282),两组比较差异有统计学意义(χ2=7.201,P=0.007);治疗前,两组患儿炎性因子、免疫球蛋白、T淋巴细胞及贫血相关指标水平比较差异无统计学意义,治疗后,两组患儿白细胞介素-2(IL-2)水平较治疗前上升,IL-4水平下降,免疫球蛋白IgG、IgA、IgM水平均较治疗前上升,T淋巴细胞CD4+水平均较治疗前上升,CD8+水平均较治疗前下降,且试验组各指标水平变化程度优于对照组(P<0.05),两组患儿贫血相关指标血红蛋白(HB)、转铁蛋白(Tf)水平均较治疗前上升,且试验组变化程度优于对照组(P<0.05)。结论对反复呼吸道感染合并贫血患儿在常规治疗的基础上联合维生素A可有效改善其临床症状,减轻其炎症反应,对其免疫功能的提高具有积极作用,效果佳,值得临床推广应用。

OBJECTIVE To explore the clinical effect of vitamin A on treatment of recurrent respiratory tract infection children complicated with anemia and observe its mechanisms.METHODS A total of 564 recurrent respiratory tract infection children complicated with anemia who were treated in Affiliated Hospital of Binzhou Medical College from May 2013 to Oct 2017 were recruited as study objects and randomly divided into the experimental group and the control group,with 282 cases in each group.All of the enrolled children were given anti-infection treatment and other symptomatic therapies,the experimental group was given additional vitamin A on basis of the treatment of the control group.The therapeutic effects were observed,the levels of inflammatory factors,immunoglobulins,T lymphocyte and anemia-related indexes were compared between the two groups of children.RESULTS The effective rate of clinical treatment of the experimental group was 90.07%(254/282),higher than 82.27%(232/282)of the control group,and there was significant difference between the two groups(χ2=7.201,P=0.007).There were no significant differences in the levels of inflammatory factors,immunoglobulins,T lymphocyte and anemia-related indexes between the two groups of children before the treatment.The interleukin-2(IL-2)level of the two groups of children was higher after the treatment than before the treatment,the IL-4 level was lower after the treatment than before the treatment,the levels of immunoglobulins IgG,IgA and IgM were higher after the treatment than before the treatment,the T lymphocyte CD4+level was higher after the treatment than before the treatment,the CD8+level was lower after the treatment than before the treatment,and the levels of the above indexes changed more significantly in the experimental group than in the control group(P<0.05).The levels of anemia-related indexes hemoglobin(HB)and transferrin(Tf)of the two groups of children were higher after the treatment than before the treatment,while the indexes changed more significantly in the experimental group than in the control group(P<0.05).CONCLUSIONThe conventional therapy combined with vitamin A may effectively improve the clinical symptoms of the recurrent respiratory tract infection children complicated with anemia and alleviate the inflammatory reactions,it has positive effect on improvement of the immune function and is worthy to be promoted in the hospital.