乙醇封管治疗和预防儿科癌症患者中心导管相关血流感染的效果研究

Review on effect of ethanol lock therapy on prevention and treatment of central line-associated bloodstream infection in pediatric cancer

中心静脉导管相关血流感染是最常见的导管相关并发症,也是医院感染管理的重点。目前,有很多关于抗生素封管或者乙醇封管等技术预防中心静脉导管相关血流感染的研究,但针对儿科癌症患者,缺乏高质量的证据证明乙醇封管能否有效预防CLABSI的发生。《柳叶刀·传染病》杂志发表的随机、双盲、对照试验提示乙醇封管在预防CLABSI中并不是最佳选择。

Central line-associated bloodstream infections(CLABSIs)are the most common catheter-related complication and also the focus of health-care associated infection management.Currently,lots of studies focus on the prevention of CLABSI with antimicrobial or ethanol lock solutions.But for children with cancer,there is a lack of high-quality evidence to prove whether ethanol lock can prevent CLABSI or not.A randomized,double-blind,controlled trial published inthe Lancet Infectious Diseases concluded that the ethanol lock therapy was not the optimal choice for prevention of CLABSI.