加替沙星联合甲硝唑片治疗尿路感染的临床效果

Clinical effect of gatifloxacin combined with metronidazole tablet on treatment of patients with urinary tract infection

目的探究加替沙星联合甲硝唑治疗尿路感染患者的效果。方法选取2016年10月-2017年10月医院接诊的100例尿路感染患者,依照治疗方法不同分成对照组和治疗组,每组各50例。对照组患者采用加替沙星治疗,治疗组在对照组基础上联合甲硝唑治疗,观察患者细菌清除率、症状消失时间和退烧时间,比较两组患者治疗前后白细胞酯酶(LEU)、尿液白细胞(WBC)计数、亚硝酸盐(NIT)、血清白细胞介素(IL)-6、IL-8、单核细胞趋化蛋白-1(MCP-1)、β2-微球蛋白(β2-MG)及尿肝素结合蛋白(HBP)的水平变化,统计患者不良反应。结果治疗组患者临床症状消失时间及退烧时间较对照组缩短,细菌清除率升高(P<0.05)。治疗后,两组患者尿液WBC计数、LEU及NIT阳性比例、血清IL-6、IL-8、MCP-1、β2-MG及HBP水平均降低,且治疗组低于对照组(P<0.05)。两组患者均出现呕吐、恶心等不良反应。结论加替沙星联合甲硝唑片治疗尿路感染的效果显著,细菌清除率较高,显著改善患者尿常规指标,减轻炎症状态和降低血清β2-MG、HBP水平。

OBJECTIVE To explore the effect of gatifloxacin combined with metronidazole on treatment of the patients with urinary tract infection.METHODS A total of 100 patients with urinary tract infection who were treated in the hospital form Oct 2016 to Oct 2017 were enrolled in the study and divided into the control group and the treatment group according to the treatment measures,with 50 cases in each group.The control group was treated with gatifloxacin,while the treatment group was treated with gatifloxacin combined with metronidazole.The bacterial clearance rate,time of disappearance of symptoms and fever reduction time of the patients were observed;the levels of leukocyte esterase(LET),urine white blood cell(WBC),nitrite(NIT),serum interleukin-6(IL-6),IL-8,monocyte chemoattractant protein-1(MCP-1),β2-microglobulin(β2-MG)and heparin-binding protein(HBP)in urine were compared between the two groups of patients before and after the treatment,and the adverse reactions were statistically analyzed.RESULTS The time of disappearance of symptoms and fever reduction time were significantly shorter in the treatment group than in the control group,while the bacterial clearance rate of the treatment group was significantly higher than that of the control group(P<0.05).The urine WBC counts,positive ratios of LET and NIT and levels of serum IL-6,IL-8,MCP-1,β2-MG and urine HBP were reduced in the two groups after the treatment,which were significantly lower in the treatment group than in the control group(P<0.05).The patients in both groups had the adverse reactions such as vomiting and nausea.CONCLUSION Gatifloxacin combined with metronidazole tablet may achieve remarkable effect on treatment of the patients with urinary tract infection,improve the routine urine test indexes,alleviate the inflammation state and reduce the levels of serumβ2-MG and HBP,with the bacterial clearance rate high.