摘要
目的研究Stathmin和Cathepsin B在人结直肠癌组织及其转移灶中的表达差异,探讨Stathmin和Cathepsin B在结直肠癌发生发展过程中的作用及其临床病理意义。方法用免疫组织化学染色技术检测158例高分化,中分化及低分化结直肠癌患者手术切除标本及64例相应转移灶组织中Stathmin蛋白和Cathepsin B蛋白的表达情况。结果 Stathmin蛋白及Cathepsin B蛋白在结直肠癌组织及其转移灶中均高表达(分别为P<0.05及P<0.01);高分化结直肠癌样本中Stathmin蛋白及Cathepsin B蛋白在细胞膜或细胞浆阳性表达,而在低分化结直肠癌细胞核,细胞膜及细胞浆中可见二者的阳性表达。结论 Stathmin及Cathepsin B可能是判断结直肠癌患者临床病理分级的有用指标。
Objective To investigate the differential expression of Stathmin and Cathepsin B in human colorectal cancer tissues and related metastatic foci and its clinicopathological significance.Methods Immunohistochemical staining for Stathmin and Cathepsin B was performed in 158 cases of colorectal cancer tissues and related 64 cases of metastatic foci within the tissue microarray.Results Both Stathmin and Cathepsin B are upregulated in colorectal cancer and related metastatic samples( P<0.05 and P<0.01 respectively ) .The location of Stathmin and Cathepsin B transferred from cytoplasm to nuclear in low differentiation colorectal cancer samples compared with high to mediate differentiation samples.Conclusion Stathmin and Cathepsin B may be valuable biomarkers for clinical differentiation of colorectal cancer.
出处
《中华结直肠疾病电子杂志》
2015年第1期45-49,共5页
Chinese Journal of Colorectal Diseases(Electronic Edition)
