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Transitions between mesenchymal and epithelial states and the concomitant gene expression changes

Transitions between mesenchymal and epithelial states and the concomitant gene expression changes
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摘要 Epithelial-mesenchymal transition(EMT),mesenchymal-epithelial transition(MET),and even the sequential EMT-MET can be observed during multiple cell fate conversions including cancer progression and embryonic development.In the current review,we first focused on the existence and beneficial roles of the sequential EMT-MET during three typical cell fate conversions,differentiation from pluripotent stem cells(PSCs)to neurons,de-differentiation from mouse embryonic fibroblasts(MEFs)to PSCs,and trans-differentiation from MEFs to neurons.We tried to provide some preliminary hypotheses to connect EMT-MET and cell fate conversions,like the possible contributions of the intermediate mesenchymal state to iPSCs generation and neurontrans-differentiation.The intermediate mesenchymal state during sequential EMT-MET was further discussed by exploring the conserved signatures on gene expression during a variety of EMT.Discussion on the interaction among vitamin C,DNA methylation,and EMT/MET was also provided. Epithelial-mesenchymal transition(EMT),mesenchymal-epithelial transition(MET),and even the sequential EMT-MET can be observed during multiple cell fate conversions including cancer progression and embryonic development.In the current review,we first focused on the existence and beneficial roles of the sequential EMT-MET during three typical cell fate conversions,differentiation from pluripotent stem cells(PSCs)to neurons,de-differentiation from mouse embryonic fibroblasts(MEFs)to PSCs,and trans-differentiation from MEFs to neurons.We tried to provide some preliminary hypotheses to connect EMT-MET and cell fate conversions,like the possible contributions of the intermediate mesenchymal state to iPSCs generation and neurontrans-differentiation.The intermediate mesenchymal state during sequential EMT-MET was further discussed by exploring the conserved signatures on gene expression during a variety of EMT.Discussion on the interaction among vitamin C,DNA methylation,and EMT/MET was also provided.
作者 LIANG LiNing SUN Hao LI LingYu ZHENG Hui
机构地区 CAS Key Laboratory of Regenerative Biology Anhui University
出处 《Science Foundation in China》 CAS 2016年第1期50-62,共13页 中国科学基金（英文版）
关键词 Epithelial-mesenchymal transition Cell FATE conversions REPROGRAMMING TRANS-DIFFERENTIATION Epithelial-mesenchymal transition Cell fate conversions Reprogramming Trans-differentiation
分类号 R346 [医药卫生—基础医学]
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参考文献86

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Science Foundation in China
2016年 第1期

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