Bacillus bombysepticus α-toxin binding to G protein-coupled receptor kinase 2 regulates cAMP/PKA signaling pathway to induce host death

With the support by the National Natural Science Foundation of China and 973 Program,Lin et al.from the State Key Laboratory of Silkworm Genome Biology,Southwest University,reported the impact and mechanism of Bacillus bombysepticus(Bb)α-toxin in GRK2-mediated GPCR desensitization that