银杏叶提取物治疗原发性高血压合并高脂血症安全性及有效性研究

Safety and Efficacy of Ginkgo Biloba Extract on Dyslipidemic-Hypertensive patients

目的探讨银行叶提取物治疗原发性高血压伴高脂血症患者的安全性和有效性。方法筛选106例原发性高血压合并高脂血症患者,在常规使用缬沙坦80~160mg·d-1降压和500mg·d-1阿昔莫司降脂治疗的基础上,53例患者(阿司匹林组)使用阿司匹林100mg·d-1抗凝治疗,另外53例患者(银杏叶组)使用银杏叶提取物治疗。分别在治疗前、治疗1、2、3个月时检测血压、血脂、血液流变学等指标及症状改善情况、不良反应等。结果治疗后,阿司匹林组和银杏叶组大部分生化指标基本恢复至正常水平,血脂、血液流变学异常也有明显的缓解(P<0.05)。与阿司匹林组相比,银杏叶组在改善症状方面的作用更为明显(P<0.01),出现不良反应率更低(P<0.05)。结论银杏叶提取物治疗原发性高血压合并高脂血症具有良好的安全性和有效性,可以作为常用抗高凝高粘滞药物用于临床。

Objective With high morbidity of hypertension and dyslipidemia,anticoagulation in the patients with high risk of myocardial infarction or stroke was necessary.Since the commonly used aspirin caused a lot of side effects,finding a safe and effective anticoagulant was urgent.This study was designed to investigate the safety and efficacy of Ginkgo biloba extract in the treatment of dyslipidemic hypertensive patients.Methods Fifty three cases treated with aspirin (AS group)and 53 cases treated with Ginkgo biloba extract (GBE group)and accompanied with antihypertensive and lipid-lowering treatment,were screened and well matched. The differences of blood pressure, blood lipids profile, hemorheology, symptom improvement and side effects were observed at the end of 1,2 and 3 months.Results The re-sults showed that most indexes were normalized in both groups after treatment.Some lipids and hemorhe-ology abnormality were obviously relieved (P <0.05),while symptoms were more markedly and quickly meliorated in GBE group than those of AS group (P <0.01)after treatment.Furthermore,GBE group had less discomfort and side effects than those of AS group (P <0.05).Conclusion GBE could be more effective with fewer side effects than aspirin in the treatment of dyslipidemic hypertensive patients.