原发性高血压患者血清Ⅲ型前胶原氨基端肽值升高及其临床价值

Serum Procollagen Type Ⅲ Aminoterminal Propeptide in Essential Hypertension

目的 检测高血压患者血清Ⅲ型前胶原氨基端肽 (PⅢNP) ,探讨其作为心肌组织纤维化指标的价值。方法 采用放免法检测 34例高血压病 (EH)患者PⅢNP含量 ,并同 2 0例同年龄血压正常的健康者作对照 ,同时检测EH患者的血管紧张素Ⅱ (AngⅡ )含量 ,超声测左室重量指数 (LVMI)及二尖瓣口舒张早期和晚期最大血流速度比值 (VE/VA)。结果 高血压组血清PⅢNP显著升高 ,血清PⅢNP与AngⅡ呈正相关 (P <0 0 1) ,与VE/VA呈负相关 (P <0 0 5 ) ,与LVMI无明显相关。结论 PⅢNP可以作为判断心肌组织纤维化进展的有价值的血清学指标 。

Objective To measure the serum concentrations of procollagen typeⅢ amino terminal propeptide (P Ⅲ NP)in essential hypertension(EH). Methods Serum P Ⅲ NP and Ang Ⅱ were measured by radioimmunoassay in 34 essential hypertensive patients and 20 normotensive subjects. Two dimensional, M mode and doppler ultrasound recordings were obtained to determine left ventricle mass index (LVMI) and maximal early transmitral flow velocity(VE)and maximal late transmitral flow velocity. Results Serum of P Ⅲ NP and Ang Ⅱ were increased in hypertensive patients as compared with normotensive subjects. Serum P Ⅲ NP correlated with the plasma concentrations of Ang Ⅱ. An inverse correlation was found between serum P Ⅲ NP and the ratio of VE/VA. No significant correlation was noted between serum P Ⅲ NP and LVMI. Conclusion These findings suggest that measurement of P Ⅲ NP may provide indirect diagnostic information on the myocardial fibrosis associated with arterial hypertension.