摘要
伏立诺他(vorinostat),化学名为N、羟基、N'、苯基辛二酰胺,首个组蛋白脱乙酰酶抑制剂类抗肿瘤药。本文以辛二酸为初始原料,与乙酸酐脱水得辛二酸酐,再经酰胺化,酯化,羟胺化一共四步反应得到目标化合物——伏立诺他,总收率达到71.5%。
Vorinostat,the chemical name for it is N-hydroxy-N'-phenyl suberic acid,is the first antineoplastic drug of histone deacetylase inhibitor.Suberic acid was selected as the start material,suberic acid anhydride was prepared with acetic anhydride by the dehydration reaction.Then,the vorinostat was obtained through amidation,estertfication and hydroxylamine process.The total yield is 71.5%.
