摘要
采用微乳液法制备了粒径为50nm的羟基磷灰石(Hydroxyapatite,HA)颗粒,并将此HA纳米颗粒与己内脂单体(caprolactone,CL)在不同的质量配比下进行原位聚合反应,得到HA/PCL高分子复合材料,然后对高分子复合材料进行红外光谱、XRD、TEM、拉力等测试,对其性能进行表征和探讨。结果表明,性能和生物相容性最接近于人骨的复合材料的HA与PCL的重量百分比为6%。
Nano-globes of hydroxyapatite with the diameter of 50 nm were synthesized by microemulsion method using diammonium hydrogen phosphate and calcium chloride as raw materials. Even more noteworthy, polycaprolactone(PCL)/HA composites were synthesized via in-situ polymerization. During the in-situ polymerization, effect of the HA contents on the structure and mechanical properties of polycaprolactone/hydroxyapatite scaffolds were investigated by scanning electron microscopy(SEM), X-ray powder diffraction(XRD) and differential scanning calorimetry(DSC), etc. It indicates that ellipsoidal polycaprolactone/hydroxyapatite composites were produced successfully. When the content of HA is up to 6 wt. %, mechanical properties of PCL/HA scaffolds were enhanced remarkably according to comparing experiments. The study provides a new way for synthesizing composites that could be used for repairing and substituting for human damaged bone, which is significant in theory and practice of bio-medicine.
