卢立康唑醇质体体外抗真菌活性研究

The antifungal susceptibility test in vitro of luliconazole ethosomes

目的检测卢立康唑醇质体体外抗菌活性。方法采用微量液基稀释法检测卢立康唑醇质体、脂质体、45%水醇溶液对皮肤癣菌、念珠菌的体外抗菌活性。结果卢立康唑醇质体对皮肤癣菌及念珠菌的MIC值低于脂质体及水醇溶液,且对毛癣菌属较念珠菌属的MIC值更低。结论卢立康唑醇质体的体外抗菌性能优于脂质体及水醇溶液。

Objective To study antifungal susceptibility of luliconazole ethosomes in vitro.Methods In vitro,antifungal activity of luliconazole ethosome,liposome,hydroalcoholic solution:MICs were determined using the micro-broth dilution assay.Results The MIC of the luliconazole ethosome was lower than that of liposome form or hydroalcoholic solution form.The MIC of luliconazole ethosome to Trichophyton spp.was lower than the sensitive degree to Candida spp.Conclusions In vitro,the antifungal effect of luliconazole ethosome is better than luliconazole liposome or its hydroalcoholic solution.