C反应蛋白基因单核苷酸多态性与家族遗传性抑郁症发病的关系研究

Relation between C-reactive protein gene polymorphisms and family inherited depression

目的研究可遗传的C反应蛋白(CRP)基因单核苷酸多态性(SNPs)分布与家族遗传性抑郁症(f DEP)发病的关系,以期进一步阐释血清CRP与抑郁症发病的关系。方法选择60例患有fDEP的男性患者作为f DEP组,并选取同期健康体检男性60例作为健康对照组。采集所有受试者的静脉血进行生化指标检查和DNA提取、CRP SNPs分析。所得数据进行统计分析。结果 f DEP组血清CRP水平显著高于健康对照组(P<0.05)。fDEP组rs1417938位点的A等位基因、rs1205位点的C等位基因以及rs1800947位点的G等位基因出现频率显著高于对照组(P<0.05)。rs1417938、rs1205位点的低频等位基因以及rs1800947位点的高频等位基因,相对于其它等位基因亚型,均可以上调血清CRP水平。结论人血液中CRP SNPs与血清CRP水平增高有关,而血清CRP水平增高可能是f DEP发病的影响因素。

Objective To investigate the relationship between C-reactive protein(CRP) gene single nucleotide polymorphisms(SNPs) and family inherited depression. Methods Sixty patients with family depression history(fDEP group) and 60 healthy subjects(control group) were recruited. The serum CRP levels were measured, and the CRP SNPs were analyzed. Results Serum CRP levels in fDEP group were significantly higher than those in control group(2.811±0.341 mg/L vs. 1.871±0.152 mg/L, P<0.05). The frequency of A allele in rs1417938, C allele in rs1205 and G allele in rs1800947 was significantly higher in fDEP group than that in control group. The AA genotype in rs1417938, CC genotype in rs1205 and GG genotype in rs1800947 were associated with serum CRP levels. Conclusion The study reveals that patients with family inherited depression have higher serum CRP levels and CRP SNPs may be associated with family inherited depression.