摘要
目的通过分析强直性脊柱炎(AS)活动期患者及骶髂关节表观扩散系数(ADC值)及加拿大脊柱关节炎评分(SPARCC),探讨弥散加权成像技术(DWI)ADC值及SPARCC评分在评估AS活动期中的价值。方法选取临床确诊为AS活动期患者17例,同时收集19例健康体检者作为正常组。对两组进行骶髂关节横断位及斜冠状位扫描。通过DWI序列及ADC图,测量患者与正常组骶髂关节(左、右髂侧及骶侧)ADC值,同时测量L5椎体中央区ADC值,比较两组骶髂关节相对ADC值(rADC)变化。同时对活动期AS患者骶髂关节行SPARCC评分,并对rADC与SPARCC评分之间的相关性进行分析。结果 DWI可显示骶髂关节炎活动期骨髓水肿情况;活动期双侧骶髂关节rADC值大于正常志愿者。活动期AS患者髂侧ADC多大于骶侧ADC,两组差异均有统计学意义(均P<0.05),活动期骶髂关节平均r ADC值与SPARCC评分呈正相关(r=0.827,P<0.05)。结论 ADC值在评价AS患者病情活动性中具有一定价值,可以对病变进行定量评估,从而可以成为判断AS活动性的重要指标。
Objective To assess the application of apparent diffusion coefficient(ADC) value in MR diffusion-weighted imaging(DWI) and Spondyloarthritis Research Consortium Canada(SPARCC) score in evaluation of activity of ankylosing spondylitis(AS).Methods Seventeen patients with clinically confirmed active AS(AS group) and 19 normal subjects(control group) were recruited in the study. Axial and oblique coronal MRI scan of sacroiliac joint was performed in two groups. And the sequences included TIWI, T2WI fs, DWI(b=0、800 s/mm2) and STIR. ADC values of sacroiliac joint(including right and left, iliac and sacral side) and center of L5 of two groups were measured through DWI sequences and ADC maps, and the changes of rADC values(the ratio of ADC values of iliac or sacral side and L5) were compared. Meanwhile, SPARCC was evaluated on the sacroiliac joints of patients with active AS, and the correlation between the average rADC value and SPARCC score of the same patient was analyzed. Results DWI showed bone marrow edema during the active stage of sacroiliitis. The rADC value of bilateral sacroiliac joints of AS group was higher than that of control group. The ADC value of iliac side of patients with active AS was higher than that of sacral side(P<0.05). The average rADC value of sacroiliac joint of AS group was positively correlated with SPARCC score(r=0.827, P<0.05). Conclusion ADC is of value in evaluation of the activity of AS, and quantitative assessment can be made on lesions through ADC value.
作者
钱琦
励杨晟
田曼曼
姜黄维
QIAN Qi;LI Yangsheng;TIAN Manman(Department of Radiology,the Third Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310005,China)
出处
《浙江医学》
CAS
2019年第6期529-532,共4页
Zhejiang Medical Journal
基金
浙江省中医药科技计划项目(2016ZB063)