牙胚、牙髓和牙周膜成纤维细胞中胰岛素样生长因子的生物学活性

The biological activity insulin-like growth factors in fibroblasts of tooth germ,dental pulp and periodontium

胰岛素样生长因子在人体和组织中有着广泛的分布 ,在胚胎发育、细胞生长分化、骨改建、神经生长等方面有重要作用。本文就近几年来胰岛素样生长因子在牙胚发育、牙髓和牙周膜成纤维细胞生长与分化、物质合成。

Insulin-like growth factors(IGFs) are distri bu ted comprehensively over the tissues of the body. They play important role in em bryogenesis, growth and differentiation of cells,bone rebuilding and growth of n erves and so on. In recent years it was concluded that IGFs were involved in too th germ development, growth and differentiation of fibroblasts in dental pulp an d periodontium, substance synthesis, repair after injury and activity of alkalin e phosphatase(ALP).This paper has reviewed those researches on this point.