犬肺通气应用雾化Gd-DTPA的MRI实验研究

An Experimental MRI Study for Pulmonary Ventilation of Dogs with Aerosolized Gadolinium-DTPA

目的 应用Gd DTPA雾化颗粒作为对比剂进行犬肺部MR成像 ,探讨其在肺实质MR成像中的作用。方法 选择北方健康家犬 6条 ,分别吸入雾化的NaCl和Gd DTPA后行MR扫描 ,通过测量肺实质信号强度 (SI)增加幅度 ,了解其在肺内的分布。结果 吸入生理盐水蒸汽后肺实质信号强度增加了 11.5 %～ 2 5 .8% ,平均 15 .8% ,与吸入空气时的信号强度相比无统计学差异 (P >0 .0 5 ) ;吸入Gd DTPA雾化颗粒后肺实质信号强度明显增加 ,增强幅度 42 .7%～ 76 .8% ,平均5 9.2 % ,与吸入空气时的信号强度相比有统计学差异 (P <0 .0 5 )。结论 雾化的Gd DTPA可以作为一种有效的肺部MRI增强对比剂 ,应用雾化Gd DTPA来获得大型实验动物的有关肺通气信息是可行的。

Objective Pulmonary MRI of dogs was performed using aerosolized gadolinium-DTPA as contrast media and its role of imaging in pulmonary parenchyma was studied. Methods Six healthy northern dogs were chosen to do MR scan after inhalation of aerosolized physiological saline solution and gadolinium-DTPA, respectively. By measuring the enhanced amplitude of signal intensity (SI) of pulmonary parenchyma, its distribution in lung was known. Results The signal intensity of pulmonary parenchyma increased by 11.5%-25.8%,averaging 15.8% after inhalation of aerosolized physiological saline solution, indicating that there was no statistic difference between inhalation of aerosolized physiological saline solution and room air( P >0.05). The signal intensity of pulmonary parenchyma increased obviously by 42.7%-76.8%, averaging 59.2% after inhalation of aerosolized gadolinium-DTPA, indicating that statistic difference occurred when compared with inhalation of room air( P <0.05). Conclusion Aerosolized gadolinium-DTPA may be used as an effective contrast agent for pulmonary MRI. It was feasible to obtain information for pulmonary ventilation of big experimental animals with aerosolized gadolinium-DTPA.[