妊娠高血压综合征患者血浆VWF和PAI-1水平的变化及临床意义

The changes and clinical significance of plasma von Willebrand factor and plasminogen activator inhibitor type-1 in pregnancy induced hypertension

目的 :探讨孕妇血浆血管性假血友病因子 (VWF)及纤溶酶原激活物抑制物 1(PAI 1)水平变化与妊高征发病的关系及其临床意义。方法 :应用酶联免疫吸附试验和发色底物法分别检测妊高征组和正常对照组孕妇血浆中VWF和PAI 1水平。结果 :(1)正常妊娠组与轻度妊高征组血浆VWF水平差异无显著性 (P >0 .0 5 ) ,正常妊娠与中、重度妊高征组差异均有显著性 (P <0 .0 5和P <0 .0 1) ;(2 )正常妊娠组血浆PAI 1水平与轻度妊高征比较 ,差异无显著性 (P >0 .0 5 ) ;正常妊娠组与中、重度妊娠组比较差异均有显著性 (P <0 .0 5和P <0 .0 1) ;(3)中、重度妊高征组血浆VWF与PAI 1水平均呈直线正相关关系 (r =0 .70 1,P <0 .0 5 ;r =0 .783,P <0 .0 5 )。结论 :孕妇血浆VWF、PAI 1水平有望成为检测妊高征病情进展的指标 ,VWF、PAI

Objective:To study the changes and clinical significance of plasma von Willebrand factor(VWF) and plasminogen activator inhibitor-1(PAI-1) levels in patients with pregnancy induced hypertension(PIH).Methods:The levels of plasma VWF and PAI-1 were detected by ELISA method and chromogenic assay respectively in 69 patients with PIH and 12 normal pregnant women respectively.Results:(1)In mild PIH patients the levels of plasma VWF and PAI-1 were not significantly higher than those in normal group(P>0.05).(2)In moderate PIH patients the parameters significantly increased compared with those in normal group (P<0.05),and so were in severe PIH group(P<0.01).(3)There was a positive correlation between the plasma VWF and PAI-1 level in moderate and severe PIH group(r=0.701,P<0.05;r=0.783,P<0.05 respectively).Conclusions:The levels of plasma VWF and PAI-1 may be two new indexes for the surveillance of PIH.It is important for the diagnosis and therapy of PIH to detect the changes of their levels.