摘要
目的 :探讨HBV感染所致的急性肝炎、慢性肝炎、肝炎肝硬化患者的细胞免疫能力的改变 ,以期从免疫角度了解该病的发病机理 ,防止病情进一步恶化 ;方法 :测定经临床确诊的急性肝炎 3 5例、慢性肝炎轻度 41例、中度 3 8例、重度 2 5例、肝炎肝硬化 3 7例及 3 0例正常人的T淋巴细胞亚群、白细胞介素 -2 (IL -2 )、可溶性白细胞介素 -2受体 (sIL -2R)的水平 ;结果 :乙型肝炎患者CD3、CD4、CD4/CD8、IL -2水平明显降低 ,CD8、sIL -2R水平明显增高 ,与正常对照比较有显著性差异 (P <0 .0 1 ) ;结论 :乙型肝炎患者细胞免疫功能严重受损 ,发生紊乱。监测细胞免疫功能 ,对判断病情发展。
Objective:To study the effects of cellular immunity on the pathogenesis of hepatitis B.Methods:A total of 206 subjects were divided into test group such as acute hepatitis group(n=35), mild chronic hepatitis(n=41), moderate chronic hepatitis(n=38), severe chronic hepatitis(n=25),posthepatitic cirrohis group(n=37), and the healthy subjects served as the normal control group(n=30). The level of T lymphocyte subpopulation, IL-2 and sIL-2R were detected respectively in all groups'serum.Results:The level of CD 3?CD 4?CD 4/CD 8 and IL-2 of the experimental groups were significantly lower than that in control(P<0.01 or P<0.05), while those of CD 8 and sIL-2R were significantly higher than those in control(P<0.01).Conclusion:There were destroy and imbalance of cellular immunity of hepatitis B, and test of cellular immunity was effective to judge the clinical development and select the efficient treatment plan.
出处
《青海医药杂志》
2003年第5期5-7,共3页
Qinghai Medical Journal
