影响肝外胆管癌预后的病理因素分析

Pathological Factors for Prognosis of Extrahepatic Cholangiocarcinoma

目的探讨肝外胆管癌的病理特征及对其预后的影响。方法回顾性分析2000年1月至2008年4月中国人民解放军空军总医院经手术切除的肝外胆管癌124例,统计病理特点并进行Cox比例风险模型分析和Kaplan-Meier分析其与患者预后的关系。结果 124例肝外胆管癌中位随访时间为75.30月,截至随访终点死亡99例(79.8%)。中位OS 24.47月,1、3和5年生存率分别为77.4%、40.3%和16.9%。结论肿瘤分化程度低、淋巴结有转移、肿瘤有局部浸润、手术切缘有癌细胞浸润是影响肝外胆管癌总生存的风险因素。

Objective To explore the effects of pathological features on the prognosis of extrahepatic cholangiocarcinoma. Methods We analyzed retrospectively 124 patients with extrahepatic cholangiocarcinoma after surgical resection in the Air Force General Hospital, PLA from January 2000 to April 2008 after surgical resection were analyzed retrospectively. The relationship between the pathological features and prognosis was analyzed by Cox proportional hazards model and Kaplan-Meier. Results The median follow-up time of 124 patients with extrahepatic cholangiocarcinoma was 75.30 months and 99 patients(79.8%) died at the end of the follow-up. The median OS was 24.47 months.The 1-, 3- and 5-year survival rates were 77.4%, 40.3% and 16.9%, respectively. Conclusion Low degree of tumor differentiation, lymphatic with metastasis, tumor with local infiltration, surgical edge with tumor cell invasion are risk factors for total survival of extrahepatic cholangiocarcinoma.