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睾丸生殖细胞肿瘤病因学研究进展 被引量：2

Advances on Etiology of Testicular Germ Cell Tumors
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摘要 睾丸生殖细胞肿瘤(TGCTs)是工业化国家年轻男性常见的恶性肿瘤之一,由于肿瘤大多形成于胎儿发育阶段,深入了解TGCTs的发病机制比较困难。本文探讨了TGCTs发病的相关因素,包括种族、地理与环境、基因与信号通路、癌干细胞、精原细胞微环境等,从而为探究TGCTs的发病机制提供基础,并为TGCTs的治疗开拓思路。 Testicular germ cell tumor(TGCT) is one of the commonest malignant tumors among young men in industrialized countries. As most tumors are formed in fetal development stage, it is difficult to have an insight into the pathogenesis. By reviewing the recent related reports, we discussed several etiologic factors of TGCTs, including race, geography, environment, related genes and signaling pathways, cancer stem cells(CSC), the niche for spermatogonial stem cells(SSCs), etc, to support investigating pathogenesis and treatment of TGCTs.
作者 秦晓东 袁欣然 李冬梅 韩晓冬
机构地区 南京大学医学院免疫与生殖生物学实验室
出处 《肿瘤防治研究》 CAS CSCD 北大核心 2014年第7期825-828,共4页 Cancer Research on Prevention and Treatment
基金 国家自然科学基金资助项目(21377052) 江苏省自然科学基金资助项目(BK20131281) 南京大学大学生创新创业训练计划项目资助课题(G1210284113)
关键词 睾丸生殖细胞肿瘤 癌干细胞 精原干细胞 Testicular germ cell tumor Cancer stem cell Spermatogonial stem cells
分类号 R737.21 [医药卫生—肿瘤]
  • 相关文献

参考文献7

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二级参考文献5

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同被引文献25

  • 1滕梁红,卢德宏,徐庆中,付永娟,杨虹,贺志立.OCT4、CD117、CD30在生殖细胞肿瘤中的表达及鉴别诊断意义[J].中华病理学杂志,2005,34(11):711-715. 被引量：27
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引证文献2

二级引证文献8

肿瘤防治研究
2014年 第7期

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