多发性骨髓瘤异常miRNAs表达的研究进展

Advances of Aberrant miRNAs Expression in Multiple Myeloma

miRNAs(microRNAs)是一类短小的非编码RNAs,通过调节基因表达的转录水平,影响细胞周期进程并起关键作用,参与细胞的增殖、代谢、凋亡与分化。miRNAs的异常表达促进肿瘤发生,包括多发性骨髓瘤(MM)。本文就miRNAs在MM中的发病机制、诊断、治疗及预后评估的最新研究进展作一综述。

miRNAs(microRNAs) are short non-coding RNAs that play critical roles in numerous cellular processes through post-transcriptional regulating functions, and participate in the regulation of cell proliferation, metabolism, apoptosis and differentiation. The dysregulation of miRNA expression contributes to tumorigenesis, including multiple myeloma(MM). In this review we summarize the current knowledge on roles of miRNAs in the pathogenesis, diagnosis, treatment and prognosis of MM.