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血管内皮生长因子C和Podoplanin对老年直肠癌淋巴结转移预后评价的价值 被引量:5

Prognostic Value of VEGF-C and Podoplanin Expressions in Rectum Cancer Tissues with Lymph Node Metastasis in Elder Patients
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摘要 目的探讨血管内皮生长因子C(VEGF-C)、Podoplanin在老年直肠癌淋巴结转移组织中的表达及其与预后的关系。方法免疫组织化学法研究VEGF-C、Podoplanin在老年直肠癌及其相应淋巴结转移癌组织中的表达,同时了解术后随访情况。结果老年直肠癌淋巴结转移组织中VEGF-C、P o d o p l a n i n的表达率均高于其相应的原发癌组织。有淋巴结转移的老年直肠癌组织V E G F-C、Podoplanin的表达显著高于无淋巴结转移的癌组织,差异有统计学意义(P<0.05)。VEGF-C、Podoplanin的表达水平和淋巴结转移是影响老年直肠癌患者预后的重要因素。结论 VEGF-C及Podoplanin在老年直肠癌淋巴结转移组织中的高表达,与直肠癌的预后有关。两者联合可以作为判断老年直肠癌淋巴结转移患者预后的检测指标。 Objective To investigate the expressions of vascular endothelial growth factor C(VEGF-C) and Podoplanin in rectum cancer tissues with lymph node metastasis in elder patients and their relationship with the prognosis. Methods VEGF-C and Podoplanin expressions in rectum carcinoma tissues and the corresponding lymph node metastasis carcinoma tissues in elder patients were detected by immunohistochemical method. At the same time the postoperative follow-up of these patients were analyzed. Results The expression rates of VEGF-C and Podoplanin in rectum carcinoma tissues with lymph node metastasis were higher than those in primary carcinoma tissues. The expressions of VEGF-C and Podoplanin in rectum carcinoma tissues with lymph node metastasis in elder patients were higher than those without lymph node(P<0.05). The levels of VEGF-C and Podoplanin and lymph node metastasis were the key factors to influence the prognosis of rectum cancer in elder patients. Conclusion VEGF-C and Podoplanin are highly expressed in rectum cancer tissues with lymph node metastasis in elder patients and related with the prognosis of rectum cancer. Their combination could be used as the index for the prognosis of rectum cancer with lymph node metastasis in elder patients.
出处 《肿瘤防治研究》 CAS CSCD 北大核心 2015年第2期164-167,共4页 Cancer Research on Prevention and Treatment
基金 江西省教育厅科学技术研究项目(GJJ14677)
关键词 老年患者 直肠癌 PODOPLANIN 血管内皮生长因子C 预后 Elder patients Rectum cancer Podoplanin Vascular endothelial growth factor C(VEGF-C) Prognosis
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