急性髓系白血病患者HOX11基因的表达及意义

Expression of HOX11 Gene in Acute Myeloid Leukemia Patients and Its Clinical Significance

目的探讨HOXll基因在急性髓系白血病(acute myeloid leukemia,AML)中的表达及对预后的影响,为个体化治疗提供依据。方法应用多重巢式RT-PCR方法对73例初诊AML患者的融合基因进行检测,对HOXll基因表达阳性和阴性的患者进行标准治疗后的疗效进行分析。结果在预后良好组、预后中等组及预后不良组AML患者的标准治疗中,HOXll基因阳性表达患者的第一疗程完全缓解率(complete remission rate)并不高于阴性表达的患者(P>0.05),而复发或死亡率(relapse or mortality rate)与HOXll基因阴性表达的患者比较差异有统计学意义(P<0.05)。结论 HOXll基因的表达可能影响AML患者的预后。

Objective To investigate the expression of HOX11 gene in acute myeloid leukemia(AML)patients and its clinical significance for prognosis, to provide evidence for individualized therapy. Methods Multiplex nested RT-PCR was performed on 73 newly diagnosed AML patients to detect fusion genes. The effect of standardized therapy was analyzed on these patients who had positive or negative HOX11 expression.Results During the standardized therapy, the complete remission rate was not higher in HOX11-positive patients with favourable prognosis AML,secondary prognosis AML,and unfavourable prognosis AML than that in HOX11-negative patients after the first course of induction therapy(P>0.05), but relapse or mortality rate was higher in HOX11-positive patients(P<0.05). Conclusion The express of HOX11 may influence the prognosis of AML.