纳米金颗粒的基本特性及其对肿瘤放射增敏作用的研究进展

Basic Characteristics of Gold Nanoparticles and Its Effect on Tumor Radiosensitization

纳米金颗粒以其独特的理化性质在医学领域越来越受到重视。近年许多研究证实了纳米金在肿瘤治疗中可以减少组织受照剂量,减轻放射治疗对正常组织的伤害,在放射增敏方面有重要作用,本文从纳米金的基本特性、生物学毒性、放射增敏机制、在细胞和动物模型中增敏实验以及在临床前应用等几方面进行综述。

With its unique physical and chemical properties, gold nanoparticles receive more and more attention in the medical f ield. In recent years, many studies have conf irmed that gold nanoparticles play an important role in radiosensitization. It can reduce tissue radiation dose and lower the radiation damage to normal tissues in cancer therapy. This paper will review the basic characteristics of gold nanoparticles, biological toxicity, radiosensitization mechanisms, radiosensitization experiments in cells and animal models, and preclinical applications.