循环肿瘤细胞监测早期膀胱癌微转移的价值

Value of Circulating Tumor Cells in Early Monitoring of Bladder Cancer Micrometastases

在过去的十年中,循环肿瘤细胞(circulating tumour cells,CTCs)作为一种新的肿瘤标志物而受到广泛关注,并被证实可能是肿瘤转移的起源而在肿瘤转移中扮演重要角色。由于CTCs能够以非侵袭性的方式从机体分离出来,因此它有助于我们更好的了解肿瘤生物学特性及转移的分子机制。在一些分期较早的癌症患者中,CTCs可作为癌症筛查、抗肿瘤治疗疗效监测及预后的标志物。本文主要阐述CTCs作为一种新的生物标志物在早期膀胱癌中的潜在临床意义。

During the past ten years, circulating tumour cells(CTCs) have received enormous attention as new biomarkers for cancer. They also have been confirmed as the origin of tumor metastasis and play an important role in tumor metastasis. Since CTCs can be isolated in a non-invasive way, they help us to better understand the molecular mechanism of tumor biological characteristics and tumor cells metastasis. In the earlier stages of some cancers, CTCs also can be used as new biomarkers for cancer screening, prognosis and monitoring the efficacy of anticancer therapies. In this review, we focus on the clinical potential value of CTCs as novel biomarkers on early bladder cancer.