食管鳞癌中上皮细胞黏附分子蛋白高表达与临床病理特征的关系

Relationship Between High Expression of Ep-CAM Protein and Clinicopathological Features of Esophageal Squamous Cell Carcinoma Tissues

目的探讨食管鳞癌标本中Ep-CAM蛋白高表达与肿瘤浸润和转移之间的关系。方法采用免疫组织化学PV-9000二步法检测140例石蜡包埋手术切除的食管鳞癌和20例癌旁正常食管上皮组织中Ep-CAM蛋白的表达,并对Ep-CAM蛋白高表达与患者临床病理特征之间的关系进行分析。结果Ep-CAM在食管鳞癌组织中高表达85例(60.7%),癌旁正常组织中不表达。Ep-CAM高表达与患者的性别无关(P=0.142),与肿瘤长度、分化程度、TNM分期、浸润深度和有无淋巴结转移均相关(P<0.05)。结论 Ep-CAM与食管鳞癌的转移和浸润相关。

Objective To explore the surgical relationship between high expression of Ep-CAM protein and the infiltration, metastasis of esophageal squamous cell carcinoma(ESCC) tissues. Methods The EpCAM expression was immunohistochemically investigated in 140 cases of primary SCC and 20 cases of adjacent non-neoplastic epithelia by PV-9000 polymer detection system for immuno-histological staining. And the relationship between clinicopathological features and high expression of Ep-CAM was analyzed. Results The high expression of Ep-CAM was observed in 85 cases(60.7%), but there was no high expression in adjacent normal tissues. Ep-CAM high expression were associated with tumor length, differentiation degree, TNM staging, infiltration depth and presence of lymph node metastasis(P<0.05), but age(P=0.142). Conclusion Ep-CAM is related to the infiltration and metastasis of ESCCs.