卵巢癌中ETV4基因高表达对患者预后的临床意义

The correlation of the high expression of ETV4 gene with prognosis of patients with ovarian cancer

目的探讨ETV4在卵巢癌中的表达及与预后的关系。方法分别利用BioGPS数据库、Oncomine数据库、癌症细胞系百科全书(CCLE)和Kaplan-Meier Plotter数据库分析ETV4基因在正常人体组织中的表达、卵巢癌组织中的表达,以及卵巢癌患者预后生存分析;利用cBioPortal数据库分析ETV4在卵巢癌中基因突变和预后关系。结果 BioGPS数据库分析结果显示ETV4在正常卵巢组织低表达;Oncomine数据库检索出340项,ETV4表达水平有差异意义的结果 32项,其中ETV4表达增高30项,ETV4表达降低2项;对符合设定条件的2项研究进行Meta分析发现,ETV4在卵巢癌组织中呈高表达状态(P<0.05);CCLE分析结果显示ETV4在卵巢癌细胞中高表达;Kaplan-Meier Plotter数据库结果显示,ETV4高表达组的卵巢癌患者总体生存时间(OS)与无病生存时间(DFS)较低表达组均显著延长(P<0.05)。cBioPortal数据库结果显示ETV4在卵巢癌中基因突变率为2.5%,但对卵巢癌患者的OS与DFS均无显著影响(P>0.05)。结论 ETV4在卵巢癌组织中高表达,且具有显著延长卵巢癌患者OS与DFS的作用,可作为卵巢癌临床预后的候选标志物;ETV4基因的突变对卵巢癌患者的OS与DFS无显著影响。

Objective To investigate the correlation of the high expression of ETS Translocation Variant(ETV4)gene with prognosis of patients with ovarian cancer.Methods The expression levels of ETV4 gene in normal human tissue and ovarian cancer tissue,and patients survival were analyzed using the BioGPS database,Oncomine database,Encyclopedia(CCLE)and Kaplan-Meier Plotter database.The relationship between the gene mutation of ETV4 in ovarian cancer and prognosis of patients was analyzed using the cBioPortal database.Results The analysis results of BioGPS database showed that the expression of ETV4 gene was low in normal ovarian tissue.Among 340 items searched from Oncomine database,32 items showed that the expression levels of ETV4 increased,and 2 items showed that the expression levels of ETV4 decreased.Meta-analysis of two studies showed that the ETV4 gene was highly expressed in ovarian cancer tissues(P<0.05).CCLE analysis showed that the ETV4 gene was highly expressed in ovarian cancer cells.Kaplan-Meier Plotter database showed that the Overall Survival(OS)and Disease Free Survival(DFS)in ovarian cancer patients with high expression levels of ETV4 gene were significantly prolonged compared with ovarian cancer patients with low expression levels of ETV4 gene(P<0.05).The results of the cBioPortal database showed that the gene mutation rate of ETV4 in ovarian cancer was 2.5%,which had no significant effect on OS and DFS in patients with ovarian cancer(P>0.05).Conclusions The ETV4 gene is highly expressed in ovarian cancer tissue,which has a significant prolongation of OS and DFS in patients with ovarian cancer,and can be used as a candidate for assessment of clinical prognosis of patients ovarian cancer.The mutation of ETV4 gene has no significant effects on the OS and DFS of ovarian cancer patients.