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老年骨肉瘤患者癌组织高迁移率族蛋白A2、SOX-2和OCT4的表达及意义

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摘要 目的检测老年骨肉瘤患者癌组织高迁移率族蛋白(HMG)A2、干细胞相关因子(SOX)-2和转录因子(OCT)4的表达及意义。方法75例骨肉瘤老年患者术后标本及临床资料作为观察组,以70例骨样骨瘤老年患者术后标本作为对照组,采用免疫组织化学方法检测HMGA2、SOX-2和OCT4的表达。结果观察组HMGA2、SOX-2和OCT4表达阳性率明显高于对照组,观察组HMGA2、SOX-2和OCT4表达阳性率与肿瘤最大径、脉管浸润、转移和Ki67的表达密切相关。观察组HMGA2、SOX-2和OCT4的表达均无明显相关性。结论老年骨肉瘤患者癌组织中HMGA2、SOX-2和OCT4表达升高,三者的异常表达可以有效促进肿瘤的发生和进展。
作者 张渊
机构地区 青海大学附属医院创伤骨科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2014年第16期4591-4593,共3页 Chinese Journal of Gerontology
关键词 骨肉瘤 HMGA2 SOX-2 OCT4
分类号 R738.1 [医药卫生—肿瘤]
  • 相关文献

参考文献14

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中国老年学杂志
2014年 第16期

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