中药痰瘀清方对老年高血压患者血栓前状态的影响

Effect of traditional Chinese medicine clearing phlegm and blood stasis on hypertension prethrombotic state

目的探讨中医痰瘀清方对老年高血压患者血栓前状态(PTS)的影响。方法选择高血压患者300例,均在入院时确定从未使用或者近1个月内未使用过任何抗凝及抗血小板药物。将300例患者随机分为三组,每组100例,A组采用自拟中医痰瘀清方治疗,B组在A组中医痰瘀清方治疗的基础上加服苯磺酸氨氯地平,C组采用苯磺酸氨氯地平口服治疗。观察3组患者治疗前、治疗后第8周血压、中医证候及血浆PTS分子标志物水平变化情况。结果 3组患者治疗8 w后收缩压、舒张压均有所下降,与治疗前比较差异均有统计学意义(P<0.05);A组和B组患者治疗8 w后收缩压、舒张压与C组治疗8 w后比较差异显著(P<0.05);B组患者治疗8 w后收缩压、舒张压与A组治疗8 w后比较差异显著(P<0.05);3组患者治疗8 w后中医证候变化情况均有所改善(P<0.05);A组和B组患者治疗8 w后中医证候改善程度与C组治疗8 w后比较差异显著(P<0.05);B组患者治疗8 w后中医证候改善程度与A组治疗8 w后比较差异显著(P<0.05);3组患者治疗8 w后血管性血友病因子(vWF)、D-二聚体(DD)、纤维蛋白原(FIB)等血浆PTS分子标志物水平均有所改善(P<0.05);A组和B组患者治疗8 w后vWF、DD、FIB等血浆PTS分子标志物水平与C组治疗8 w后比较差异显著(P<0.05);B组患者治疗8 w后vWF、DD、FIB等血浆PTS分子标志物水平与A组治疗8 w后比较差异显著(P<0.05)。结论中医痰瘀清方治疗老年高血压效果显著,能够改善高血压患者PTS。

Objective To investigate the effect of clearing phlegm and blood stasis on hypertension prothrombotic status (PTS). Methods 300 cases of hypertension patients were selected .All of the subjects were determined at the time of admission never use or nearly 1 months did not use any anticoagulation and antiplatelet drugs .300 patients were randomly divided into three groups , 100 cases in each group, group A with traditional Chinese medicine phlegm clearing treatment , in group B, based on group A of phlegm stasis clear treatment with amlodipine besylate oral treatment , group C with amlodipine besylate oral treatment .Blood pressure , TCM syndrome , plasma PTS mo-lecular markers were observed before treatment and after eighth weeks of treatment .Results After 8 weeks of treatment , systolic pressure, diastolic pressure were decreased compared with those before treatment of 3 groups (P<0.05).There were significant differences in systolic pressure, diastolic pressure between A, B groups and C group and A and B group 8 weeks after the treatment (P<0.05).There were signifi-cant differences in TCM syndrome of 3 groups between before treatment and 8 weeks after treatment (P<0.05).There were significant differ-ences in TCM syndrome on 8 weeks after treatment between A , B groups and C group and A and B group (P<0.05).There were significant differences in vWF, DD, FIB of 3 groups between before treatment and 8 weeks after treatment (P<0.05).There were significant differ-ences in vWF, DD, FIB on 8 weeks after treatment between A , B groups and C group and A and B group (P<0.05).Conclusions Effect of clearing phlegm and blood stasis on elderly hypertensive is obvious and can improve the patients 'PTS.