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基于ZnT8表位肽和BTLA的疫苗对CD8^+T细胞的免疫抑制效应 被引量：2

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摘要 目的探讨ZnT8表位肽和B、T淋巴细胞弱化因子(BTLA)的疫苗对CD8+T细胞的免疫抑制效应。方法制备含有ZnT8表位肽和BTLA的疫苗,免疫人外周血单个核细胞,观察对CD8+T细胞的抑制效应。结果基于ZnT8表位肽和BTLA的疫苗抑制人外周血单个核细胞的CD8+T细胞增殖和活化。结论基于ZnT8表位肽和BTLA的疫苗对CD8+T细胞具有免疫抑制效应,为1型糖尿病的治疗提供了理论基础。
作者 石雁冰 郉立志 李树法 张媛媛 张兰举 马桂洁 姜春艳
机构地区 贵阳中医学院第一附属医院门诊部 临沂市人民医院内分泌科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2014年第19期5505-5507,共3页 Chinese Journal of Gerontology
基金 贵州省科技厅基金项目资助(黔科合SY〔2011〕3049 黔科合SY〔2012〕3139)
关键词 锌转运体8 B/T淋巴细胞弱化因子 CD8+T细胞 1型糖尿病
分类号 R392 [医药卫生—免疫学]
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参考文献8

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共引文献1

同被引文献32

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二级引证文献9

中国老年学杂志
2014年 第19期

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