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老年女性急性ST段抬高心肌梗死患者的临床特点及近期预后 被引量:4

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摘要 目的了解老年女性急性ST段抬高心肌梗死(STEMI)患者的发病特点及性别差异对近期预后的影响。方法连续收集2012年1月至2013年12月入住该院心内科的老年STEMI患者354例,其中女性99例(28.0%)。观察老年女性STEMI患者的临床特点、治疗情况、死亡及6个月内主要不良心血管事件。结果与老年男性患者比较,老年女性患者平均年龄较大,合并高血压和2型糖尿病比例较高(P<0.05)。超敏C反应蛋白、总胆固醇水平和血清总蛋白水平较高,而血红蛋白浓度较低(P<0.05)。冠状动脉造影结果显示老年女性患者罪犯血管TIMI血流分级较差(P<0.05),更倾向于术中应用血栓抽吸治疗,但接受血小板糖蛋白Ⅱb/Ⅲa受体拮抗剂治疗的比例低于老年男性组(42.4%vs 72.5%,P<0.001)。老年女性患者MACE发生率显著高于老年男性患者组(30.3%vs 15.7%,P=0.017)。在所有MACE中,老年女性患者心源性死亡的发生率显著高于男性(P<0.05)。多因素COX风险比例回归分析发现女性、高龄、低的左室射血分数(LVEF)和冠脉多支血管病变是预后的独立危险因素。结论老年女性STEMI患者病情危重,死亡率高。女性、高龄、低LVEF和冠脉多支病变是STEMI患者预后的独立危险因素。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2014年第24期6853-6856,共4页 Chinese Journal of Gerontology
基金 国家自然科学基金青年项目(81400200)
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