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白细胞介素-17及类风湿因子联合检测在老年类风湿关节炎诊断中的应用 被引量:2

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摘要 目的研究白细胞介素(IL)-17及类风湿因子(RF)联合检测在老年类风湿关节炎(RA)诊断中的价值。方法接受治疗RA患者49例为观察组,另纳入同期健康体检者51例为对照组。结果观察组血清RF水平显著高于对照组(t=9.895,P<0.001);观察组血清IL-17水平显著高于对照组(t=5.311,P<0.001)。采用Pearson相关性检验分析显示:观察组血清IL-17与RF水平呈现显著正相关(r=0.685,P<0.001)。受试者操作特征(ROC)曲线分析显示,采用RF联合IL-17诊断RA可获得最佳的诊断敏感性(90.9%)及特异性(95.6%),优于RF或IL-17单独检测。结论 RA患者外周血高表达IL-17,且IL-17及RF联合检测可提高RA诊断率。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2015年第9期2486-2487,2488,共3页 Chinese Journal of Gerontology
基金 国家自然科学基金项目(No.81360672)
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参考文献11

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