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香烟作用于肺部原代细胞影响慢阻肺气道重构的研究进展

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摘要 慢性阻塞性肺疾病(COPD)的主要病理改变发生在呼吸道、肺实质以及肺部血管〔1〕。在细胞水平下研究COPD的病理机制既可以采用永生化的细胞株,也可以采用原代细胞体外培养模型,但原代细胞直接来源于机体组织,生物性状尚未发生大的变化,在一定程度上能够更好地反映体内的状态和功能。因此,原代细胞体外培养模型逐渐称为研究包括COPD在内的疾病的病理机制的重要实验对象。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2015年第12期3466-3469,共4页 Chinese Journal of Gerontology
基金 国家自然科学基金资助项目(No.11172340) 重庆市科委百名杰出科技领军人才培养计划 高等学校博士学科点专项科研基金(新教师类,No.20120191120032) 重庆市自然科学基金计划一般项目(No.cstc2012jj A0588) 中央高校基本科研业务费(No.CQDXWL-2012-123 CQDXWL-2013-028)
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