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依达拉奉对于急性脑梗死溶栓患者MMP-9水平及出血性转化的影响 被引量:18

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摘要 重组组织型纤溶酶原激活物(rt-PA)是美国食品和药品监督管理局(FDA)唯一批准使用于急性缺血性卒中溶栓治疗的药物,时间窗内rt-PA静脉溶栓为目前公认的改善缺血性卒中结局最有效的治疗方法,有效改善血管再通及神经功能损伤〔1〕。NINDS〔2〕、亚特兰蒂斯(ALTLANTIS)以及欧洲协作急性卒中研究(ECASS)等临床研究结果都证明了卒中3 h内使用rt-PA静脉溶栓安全有效〔3〕,
出处 《中国老年学杂志》 CAS CSCD 北大核心 2015年第13期3788-3790,3791,共4页 Chinese Journal of Gerontology
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  • 1Colin A. Graham,Rebecca W.Y. Chan,Dexter Y.S. Chan,Cangel P.Y. Chan,Lawrence K.S. Wong,Timothy H. Rainer.Matrix metalloproteinase 9 mRNA: An early prognostic marker for patients with acute stroke[J]. Clinical Biochemistry . 2011 (4-5)
  • 2Kazumi Kimura,Juya Aoki,Yuki Sakamoto,Kazuto Kobayashi,Kenichi Sakai,Takeshi Inoue,Yasuyuki Iguchi,Kensaku Shibazaki.Administration of edaravone, a free radical scavenger, during t-PA infusion can enhance early recanalization in acute stroke patients — A preliminary study[J]. Journal of the Neurological Sciences . 2011 (1)
  • 3Phil Lee,Jieun Kim,Rachel Williams,Rajat Sandhir,Eugene Gregory,William M. Brooks,Nancy E.J. Berman.Effects of aging on blood brain barrier and matrix metalloproteases following controlled cortical impact in mice[J]. Experimental Neurology . 2011 (1)
  • 4Watanabe Toshiaki,Tahara Munenori,Todo Satoru.The novel antioxidant edaravone: from bench to bedside. Cardiovascular therapeutics . 2008
  • 5Solveig Horstmann,Pamela Kalb,James Koziol,Humphrey Gardner,Simone Wagner.Profiles of Matrix Metalloproteinases, Their Inhibitors, and Laminin in Stroke Patients: Influence of Different Therapies[J]. Stroke: Journal of the American Heart Association . 2003 (9)
  • 6Hacke W,Donnan G,Fieschi C,et al.Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials[].The Lancet.2004
  • 7Edaravone Acute Infarction Study Group.Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction.Randomized, placebo-controlled, double-blind study at multicenters[].Cerebrovascular Diseases.2003
  • 8Sharma Pawan,Sinha Manish,Shukla R,Garg R K,Verma R,Singh M K.A randomized controlled clinical trial to compare the safety and efficacy of edaravone in acute ischemic stroke. Annals of Indian Academy of Neurology . 2011
  • 9Hacke Werner,Kaste Markku,Bluhmki Erich,Brozman Miroslav,Dávalos Antoni,Guidetti Donata,Larrue Vincent,Lees Kennedy R,Medeghri Zakaria,Machnig Thomas,Schneider Dietmar,von Kummer Rüdiger,Wahlgren Nils,Toni Danilo.Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. The New England Quarterly . 2008
  • 10Pernilla Svedin,Henrik Hagberg,Karin S?vman,Changlian Zhu,Carina Malla.Matrix Metalloproteinase-9 Gene Knock-out Protects the Immature Brain after Cerebral Hypoxia?Ischemia. The Journal of Neuroscience . 2007

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