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蛋白激酶在脊髓损伤中作用机制的研究进展

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摘要 脊髓损伤(SCI)分为原发性脊髓损伤和继发性脊髓损伤〔1〕。炎性因子、活性氧、兴奋性毒性和代谢异常是导致继发性损伤的主要原因。正常或病理条件下,磷酸酶和张力蛋白同源物(PTEN)/磷脂酰肌醇3激酶(PI3K)、丝裂原活化蛋白激酶(MAPK)信号通路在中枢神经系统(CNS)中扮演着不同的角色,两条通路的激活均能够诱导细胞结构和功能的改变。
作者 郭垠利 白洁
机构地区 昆明理工大学医学院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2015年第15期4382-4385,共4页 Chinese Journal of Gerontology
基金 国家自然科学基金(No.81160162 U1202227)
关键词 脊髓损伤 磷酸酶和张力蛋白同源物/磷脂酰肌醇3激酶 丝裂原活化蛋白激酶 中枢神经系统
分类号 R651.2 [医药卫生—外科学]
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  • 2Pingping Zhu,Lixuan Zhan,Tingna Zhu,Donghai Liang,Jiaoyue Hu,Weiwen Sun,Qinghua Hou,Huarong Zhou,Baoxing Wu,Yanmei Wang,En Xu.The Roles of p38 MAPK/MSK1 Signaling Pathway in the Neuroprotection of Hypoxic Postconditioning Against Transient Global Cerebral Ischemia in Adult Rats[J]. Molecular Neurobiology . 2014 (3)
  • 3Yosuke Ohtake,Dongsun Park,P.M. Abdul-Muneer,Hui Li,Bin Xu,Kartavya Sharma,George M. Smith,Michael E. Selzer,Shuxin Li.The effect of systemic PTEN antagonist peptides on axon growth and functional recovery after spinal cord injury[J]. Biomaterials . 2014
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共引文献7

中国老年学杂志
2015年 第15期

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