摘要
目的综合评价血浆可溶性糖基化终产物受体(sRAGE)水平与慢性阻塞性肺疾病的关系。方法通过计算机联网检索中国生物医学文献数据库、中国学术期刊全文数据库、Medline、Pubmed等数据库,收集2014年4月以前国内外公开发表的有关血浆sRAGE水平与慢性阻塞性肺疾病关系的研究文献。按照纳入与排除标准,选择6篇文献进行Meta分析。结果经Meta分析一致性检验,各研究结果间存在异质性,采用随机效应模型,其合并标准化均数差(SMD)值可信区间(CI)为-1.15,95%CI-1.62^-0.68。结论血浆sRAGE水平降低提示增加COPD发生的风险。
Objective To evaluate the relationship between plasma sRAGE level and COPD. Methods These papers about the relationship between plasma sRAGE level and COPD published before April 2014 were collected from CMB,CNKI,Medline,Pubmed and so on. According to inclusion and exclusion criteria,a total of 6 related papers were suitable for meta-analysis. Results Meta-analysis showed these papers were inhomogeneous. Therefore a random effect model was used. Standard mean was different and 95% CI were- 1. 17(- 2. 05^- 0. 29). Conclusions The decrease of plasma sRAGE level increases the risk of COPD.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2015年第17期4914-4915,共2页
Chinese Journal of Gerontology
基金
国家自然科学基金项目(71273077)
