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骨髓间充质干细胞治疗脑梗死的研究进展 被引量:1

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摘要 脑梗死是常见的脑血管病类型,因脑血管供血障碍而引发缺血性级联反应,造成神经功能缺损。随着人口老龄化,其发病率逐年上升,成为人类死亡和残疾的主要病因之一。目前,针对脑梗死的溶栓治疗因严格的时间窗而限制了获益患者。传统药物治疗虽然使疾病死亡率有所下降,但多数患者仍残存神经功能缺损,严重影响患者生活质量。自干细胞移植理论的兴起,骨髓间充质干细胞(BMSCs)移植治疗脑梗死的研究中发现移植BMSCs可促进脑梗死后功能改善〔1〕和组织修复〔2〕,
出处 《中国老年学杂志》 CSCD 北大核心 2015年第19期5644-5646,5647,共4页 Chinese Journal of Gerontology
基金 国家自然科学基金资助课题(No.81160148)
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  • 1Liu‐Qing Wang,Zhen‐Zhen Lin,Hong‐Xia Zhang,Bei Shao,Li Xiao,Hui‐Gang Jiang,Qi‐Chuan Zhuge,Luo‐Kun Xie,Brian Wang,Dong‐Ming Su,Kun‐Lin Jin.Timing and Dose Regimens of Marrow Mesenchymal Stem Cell Transplantation Affect the Outcomes and Neuroinflammatory Response After Ischemic Stroke[J]. CNS Neurosci Ther . 2014 (4)
  • 2Seung-Wan Yoo,Da-Young Chang,Hye-Sun Lee,Gyu-Hee Kim,Jin-Sung Park,Buom-Yong Ryu,Eun-Hye Joe,Young-Don Lee,Sung-Soo Kim,Haeyoung Suh-Kim.Immune following suppression mesenchymal stem cell transplantation in the ischemic brain is mediated by TGF-β[J]. Neurobiology of Disease . 2013
  • 3J.S. Heo,S.-M. Choi,H.O. Kim,E.H. Kim,J. You,T. Park,E. Kim,H.-S. Kim.Neural transdifferentiation of human bone marrow mesenchymal stem cells on hydrophobic polymer-modified surface and therapeutic effects in an animal model of ischemic stroke[J]. Neuroscience . 2013
  • 4Cindy T.J. van Velthoven,R. Ann Sheldon,Annemieke Kavelaars,Nikita Derugin,Zinaida S. Vexler,Hanneke L.D.M. Willemen,Mirjam Maas,Cobi J. Heijnen,Donna M. Ferriero.Mesenchymal Stem Cell Transplantation Attenuates Brain Injury After Neonatal Stroke[J]. Stroke . 2013 (5)
  • 5Ling Wei,Jamie L. Fraser,Zhong-Yang Lu,Xinyang Hu,Shan Ping Yu.Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells enhances angiogenesis and neurogenesis after cerebral ischemia in rats[J].Neurobiology of Disease.2012(3)
  • 6YanChun Zhao,Jie Xin,ChunHui Sun,BaoXiang Zhao,Jing Zhao,Le Su.Safrole oxide induced neuronal differentiation of rat bone-marrow mesenchymal stem cells by elevating Hsp70[J]. Gene . 2012 (1)
  • 7L.H. SHEN,M. YE,X.S. DING,Q. HAN,C. ZHANG,X.F. LIU,H. HUANG,E.B. WU,H.F. HUANG,X.S. GU.Protective effects of MCI-186 on transplantation of bone marrow stromal cells in rat ischemic stroke model[J]. Neuroscience . 2012
  • 8Shuhua Yang,Qing Gao,Lihua Bao,Jing Zhang,Yanlai Hu,Lujun Bing,Jinlong Sun,Jing Hao,Chao Chen,Shangzhi Li,W.S. Poon,Jinhao Sun,Yingmao Gao.Striatal extracts promote the dopaminergic differentiation of GFP-bone mesenchymal stem cells[J]. Neuroscience Letters . 2012 (2)
  • 9Immunomodulatory influence of bone marrow-derived mesenchymal stem cells on neuroinflammation in astrocyte cultures[J]. Journal of Neuroimmunology . 2012 (1-2)
  • 10Barbara Steiner,Manfred Roch,Nikola Holtkamp,Andreas Kurtz.Systemically administered human bone marrow-derived mesenchymal stem home into peripheral organs but do not induce neuroprotective effects in the MCAo-mouse model for cerebral ischemia[J]. Neuroscience Letters . 2012 (1)

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