期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

人胰高血糖素样肽-1受体激动剂的作用机制 被引量：7

下载PDF
导出
摘要 1987年Nauck等〔1,2〕人证实了肠促胰素效应的存在,且发现2型糖尿病(T2DM)患者餐后胰高血糖素样肽(GLP)-1水平较正常人明显降低,这提示肠促胰素异常可能是T2DM的发病机制之一。此后,两种重要的肠促胰素,葡萄糖依赖性促胰岛素多肽(GIP)与GLP-1被相继发现。但由于GIP在T2DM患者中的分泌接近正常或仅轻微下降。
作者 翁建平
机构地区 中山大学附属第三医院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2015年第20期5981-5983,5983,共3页 Chinese Journal of Gerontology
关键词 胰高血糖素样肽-1受体激动剂 糖尿病
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献18

  • 1Vivian A. Fonseca,J. Hans DeVries,Robert R. Henry,Morten Donsmark,Henrik F. Thomsen,Jorge Plutzky.Reductions in systolic blood pressure with liraglutide in patients with type 2 diabetes: Insights from a patient-level pooled analysis of six randomized clinical trials[J]. Journal of Diabetes and Its Complications . 2014
  • 2Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction[J]. European Heart Journal . 2012 (12)
  • 3Karen Elkind-Hirsch,Ory Marrioneaux,Madhu Bhushan,Denise Vernor,Rajat Bhushan.Comparison of Single and Combined Treatment with Exenatide and Metformin on Menstrual Cyclicity in Overweight Women with Polycystic Ovary Syndrome[J]. The Journal of Clinical Endocrinology & Metabolism . 2008 (7)
  • 4M. A. Nauck,S. Duran,D. Kim,D. Johns,J. Northrup,A. Festa,R. Brodows,M. Trautmann.A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: a non-inferiority study[J]. Diabetologia . 2007 (2)
  • 5Daniel J Drucker,Michael A Nauck.The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes[J]. The Lancet . 2006 (9548)
  • 6B. E. Dunning,J. E. Foley,B. Ahrén.Alpha cell function in health and disease: influence of glucagon-like peptide-1[J]. Diabetologia . 2005 (9)
  • 7Juris J. Meier,Baptist Gallwitz,Stefan Salmen,Oliver Goetze,Jens J. Holst,Wolfgang E. Schmidt,Michael A. Nauck.Normalization of Glucose Concentrations and Deceleration of Gastric Emptying after Solid Meals during Intravenous Glucagon-Like Peptide 1 in Patients with Type 2 Diabetes[J]. The Journal of Clinical Endocrinology & Metabolism . 2003 (6)
  • 8Reduced incretin effect in Type 2 (non-insulin-dependent) diabetes[J]. Diabetologia . 1986 (1)
  • 9Meier Juris J,Nauck Michael A,Kranz Daniel,Holst Jens J,Deacon Carolyn F,Gaeckler Dirk,Schmidt Wolfgang E,Gallwitz Baptist.Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects. Diabetes . 2004
  • 10Kreymann B,Ghatei MA,Williams G,et al.Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet,The . 1987

共引文献5

同被引文献61

  • 1李震花,葛志明.糖尿病性动脉粥样硬化加速的机制[J].中国老年学杂志,2006,26(4):564-565. 被引量：14
  • 2刘友章,丁站新,宋雅芳,符小聪.为脾正名 替小肠申冤[J].中华中医药学刊,2007,25(4):654-655. 被引量：18
  • 3Koshiyama A, Ichibangase T, Imai K, et al. Comprehensive fluoro-genic derivatization -liquid chromatography/tandem mass spec-trometry proteomic analysis of colorectal cancer cell to identifybiomarker candidate[J]. Biomed Chromatogr, 2013,27(4):440-450.
  • 4Luo J, Lin HC, He K, et al. Diabetes and prognosis in older personswith colorectal cancer[J]. Br J Cancer, 2014,110(7):1847-1854.
  • 5Lee KS, Shin JS, Kwon YS, et al. Suppression of Cancer Progres-sion and Metastasis in HT-29 Human Colorectal Adenocarcinomasby Deep Sea Water[J]. Biotechnology and Bioprocess Engineering,2013,18(1):194-200.
  • 6Kim S,Lee S, Maeng YH,et al. Study of Metabolic ProfilingChanges in Colorectal Cancer Tissues Using ID 1H HR 一MASNMR Spectroscopy [J]. Bulletin of the Korean Chemical Society,2013,34(5):1467-1472.
  • 7Chen Y, Chen G, Feng S, et al, Label-free serum ribonucleic acidanalysis for colorectal cancer detection by surface -enhanced Ra-man spectroscopy and multivariate analysis[J]. J Biomed Opt, 2012,17(6):067003.
  • 8Koole C, Wootten D, Simms J, et al. Second extracellular loop ofhuman glucagon-like peptide-1 receptor (GLP-1R) has a criticalrole in GLP-1 peptide binding and receptor activation [J]. J BiolChem, 2012,287(6):3642-3658.
  • 9张骁,束梅英,张韬.胰高血糖素样肽-1受体激动剂治疗2型糖尿病的研究进展[J].中国执业药师,2010,7(3):3-8. 被引量：15
  • 10纪立农.肠促胰素在2型糖尿病治疗中的作用[J].中华内分泌代谢杂志,2010,26(8):737-740. 被引量：11

引证文献7

二级引证文献17

中国老年学杂志
2015年 第20期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部