ER、PR和p53在老年子宫内膜癌患者中的表达及意义

Expressions and significance of ER,PR,p53 in senile patients with endometrial carcinoma

目的探讨雌激素受体(ER)、孕激素受体(PR)和p53在老年子宫内膜癌患者中的表达及意义。方法采用免疫组织化学Envision法检测21例老年子宫内膜癌(老年组)与40例非老年子宫内膜癌(非老年组)患者中ER、PR和p53蛋白的表达。结果 ER、PR、p53阳性率在老年组和非老年组中分别为71.4%、76.2%、81%和77.5%、90%、57.5%,PR表达在两组间有显著性差异(P=0.036)。p53阳性表达与年龄呈正相关(r=0.279,P=0.029)。结论 PR和p53在不同年龄子宫内膜癌中的表达差异与肿瘤生物学行为及预后有一定关系。老年患者的PR表达较非老年患者显著降低,而这会影响两组人群孕激素的治疗效果。

Objective To investigate the expressions of estrogen receptor ( ER) ,progesterone receptor ( PR) and p53 in senile pa-tients with endometrial carcinoma and their clinical importance.Methods The expressions of ER,PR and p53 in 21 senile patients ( senile group) and 40 nonsenile patients ( nonsenile group) with endometrial carcinoma were tested by immunohistochemistry Envision method.Re-sults The positive rates of ER,PR,p53 in senile group and nonsenile group were 71.4%,76.2%,81% and 85%,90%,57.5%,respec-tively.The expression of PR between the two groups was significantly different ( P=0.036) .The positive expression of p53 was increased with age advanced (r=0.279,P=0.029).Conclusions The expression discrepancy of PR and p53 in different ages of endometrial carcinoma might be related to tumor biological behavior and prognosis.The expression of PR is significantly decreased in senile group compared with that in nonsenile group,and this would affect the treatment outcome of progesterone in the two groups.