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N-甲基-D-天冬氨酸受体在可卡因成瘾中作用的研究进展 被引量：2

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摘要 活动依赖的突触传递能效的改变,在多种记忆学习中起着重要的作用。药物成瘾的过程中,往往伴随着突触传递效能的改变。研究发现,参与成瘾的分子机制与突触可塑性的分子机制有很大重合。有观点认为成瘾是一种异常的学习记忆行为。在可卡因成瘾中,不仅在不同脑区有突触可塑性的产生,而且兴奋性突触可塑性的分子开关-N-甲基-D-天冬氨酸受体(NMDA)的组成及其生理特性都发生了改变。
作者 贾祥磊 张继川
机构地区 昆明理工大学医学院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2015年第21期6285-6288,6288,共4页 Chinese Journal of Gerontology
基金 国家自然科学基金(NFSC3117105)
关键词 可卡因 成瘾 NMDA受体 可塑性
分类号 R749.64 [医药卫生—神经病学与精神病学]
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参考文献9

  • 1Tifei Yuan,Manuel Mameli,Eoin C. O’ Connor,Partha Narayan Dey,Chiara Verpelli,Carlo Sala,Isabel Perez-Otano,Christian Lüscher,Camilla Bellone.Expression of Cocaine-Evoked Synaptic Plasticity by GluN3A-Containing NMDA Receptors[J]. Neuron . 2013 (4)
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  • 9王玉兰,徐铁军,樊红彬,张凤真,王梅申,彭裕文.生后早期大鼠海马NMDA受体亚单位NR1、NR2A和NR2B的表达变化[J].神经解剖学杂志,2003,19(4):413-418. 被引量：11

二级参考文献17

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中国老年学杂志
2015年 第21期

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