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IKKε/TBK1信号通路调控与致癌作用的研究进展 被引量：2

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摘要 IKKε和TBK1是2个IκB激酶(IKK)相关激酶,他们之间形成异源二聚体,共同参与调控干扰素调节因子(IRF)与核因子(NF)-κB的信号级联,从而调控天然免疫和炎症代谢疾病,甚至肿瘤的形成。IKKε和TBK1在NF-κB信号通路活化过程中与经典的IKK(IKKα、IKKβ)都具有磷酸化靶点的作用,所以国外学者多把IKKε和TBK1称为NF-κB的额外活化激酶,
作者 唐人民 李俊明 邹秀兰
机构地区 三峡大学人民医院宜昌市第一人民医院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2015年第23期6918-6921,共4页 Chinese Journal of Gerontology
基金 国家自然科学基金资助项目(81270280)
关键词 IKKε TBK1 核因子-ΚB 干扰素调节因子 肿瘤
分类号 R730.2 [医药卫生—肿瘤]
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参考文献23

  • 1Clark Kristopher,Takeuchi Osamu,Akira Shizuo,Cohen Philip.The TRAF-associated protein TANK facilitates cross-talk within the I{kappa}B kinase family during Toll-like receptor signaling. Proceedings of the National Academy of Sciences of the United States of America . 2011
  • 2Mitsuharu Sato,Tadatsugu Taniguchi,Nobuyuki Tanaka.??The interferon system and interferon regulatory factor transcription factors – studies from gene knockout mice(J)Cytokine and Growth Factor Reviews . 2001 (2)
  • 3Lawrence Toby,Bebien Magali,Liu George Y,Nizet Victor,Karin Michael.IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature . 2005
  • 4Yuchen Chien,Sungchan Kim,Ron Bumeister,Yueh-Ming Loo,Sung Won Kwon,Cynthia L. Johnson,Mirey G. Balakireva,Yves Romeo,Levy Kopelovich,Michael Gale,Charles Yeaman,Jacques H. Camonis,Yingming Zhao,Michael A. White.RalB GTPase-Mediated Activation of the IκB Family Kinase TBK1 Couples Innate Immune Signaling to Tumor Cell Survival[J]. Cell . 2006 (1)
  • 5Hemmi Hiroaki,Takeuchi Osamu,Sato Shintaro,Yamamoto Masahiro,Kaisho Tsuneyasu,Sanjo Hideki,Kawai Taro,Hoshino Katsuaki,Takeda Kiyoshi,Akira Shizuo.The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. The Journal of experimental medicine . 2004
  • 6Jakub Siednienko,Thusitha Gajanayake,Katherine A. Fitzgerald,Paul Moynagh,Sinéad M. Migg.Absence of MyD88 Results in Enhanced TLR3-Dependent Phosphorylation of IRF3 and Increased IFN-β and RANTES Production. J. Immunol . 2011
  • 7Kiyonaga Fujii,Shingo Nakamura,Kiyohiro Takahashi,Fuyuhiko Inagaki.Systematic characterization by mass spectrometric analysis of phosphorylation sites in IRF-3 regulatory domain activated by IKK-i[J]. Journal of Proteomics . 2010 (6)
  • 8E. Niederberger,C. V. Moser,K. L. Kynast,G. Geisslinger.??The Non-Canonical IκB Kinases IKKε and TBK1 as Potential Targets for the Development of Novel Therapeutic Drugs(J)Current Molecular Medicine . 2013 (7)
  • 9Guan H,Zhang H,Cai J,et al.IKBKE is over-expressedin glioma and contributes to resistance of glioma cells to apop-tosis via activating NF-κB. Journal of Paleopathology . 2011
  • 10Kravchenko Vladimir V,Mathison John C,Schwamborn Klaus,Mercurio Frank,Ulevitch Richard J.IKKi/IKKepsilon plays a key role in integrating signals induced by pro-inflammatory stimuli. Journal of Biological Chemistry . 2003

二级参考文献35

  • 1Honda K, Yanai H, Takaoka A, Taniguchi T. Regulation of the type I IFN induction: a current view. Int Immunol 2005; 17:1367-78.
  • 2Medzhitov R ,Janeway CA Jr. Decoding the patterns of self and nonself by the innate immune system. Science 2002; 296:298-300.
  • 3Akira S Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004; 4:499-511.
  • 4Yoneyama M, Kikuchi M, Natsukawa T, et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 2004; 5:730-7.
  • 5Maniatis T, Falvo JV, Kim TH, et al. Structure and function of the interferon-beta enhanceosome. Cold Spring Harb Symp Quant Biol 1998; 63:609-620.
  • 6Silverman N, Maniatis T. NF-kappa B signaling pathways in mammalian and insect innate immunity. Genes Dev 2001;15:2321-42.
  • 7Fitzgerald KA, Mc Whirter SM, Faia KL, et al. IKKepsilon and TBKI are essential components of the IRF3 signaling pathway.Nat Immunol 2003; 4:491-6.
  • 8Sharma S, tenOever BR, Grandvaux N, et al. Triggering the interferon antiviral response through an IKK-related pathway.Science 2003; 300:1148-51.
  • 9Honda K, Yanai H, Negishi H, et al, IRF-7 is the master regulator of type-Ⅰ interferon-dependent immune responses, Nature 2005;434:772-7.
  • 10Takaoka A Yanai H, Kondo S, et al. Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors.Nature 2005; 434:243-9.

共引文献50

同被引文献22

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二级引证文献2

中国老年学杂志
2015年 第23期

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