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小胶质细胞与β淀粉样蛋白致阿尔茨海默病研究进展 被引量：5

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摘要 阿尔茨海默病(AD)主要表现为进行性记忆和认知功能下降,行为异常和社交障碍〔1〕。其主要病理改变是大脑皮层和海马等脑区神经细胞外老年斑(SP)形成、神经细胞内出现神经纤维缠结(NFT)、神经突触丢失和神经元大量死亡〔2,3〕。AD患者脑内出现大量蛋白样沉淀及神经纤维的交联。β-淀粉样蛋白(Aβ)是脑内蛋白样沉淀最重要的组成部分〔4〕。尽管AD发病机制目前还不十分明确。
作者 狄婷婷 王瑞婷
机构地区 承德护理职业学院 承德医学院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2015年第24期7270-7272,共3页 Chinese Journal of Gerontology
基金 河北省教育厅重点资助课题(ZD20131051) 河北省高校省级重点学科资助项目(20130337)
关键词 阿尔茨海默病(AD) 小胶质细胞 Β淀粉样蛋白
分类号 R749.16 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献27

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  • 4Kauppinen Tiina M,Suh Sang Won,Higashi Youichirou,Berman Ari E,Escartin Carole,Won Seok Joon,Wang Chao,Cho Seo-Hyun,Gan Li,Swanson Raymond A.Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β. Journal of neuroinflammation . 2011
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二级参考文献128

  • 1郭峰,屈秋民,韩建峰,乔晋,杨华,武成斌.阿尔茨海默病患者血清IL-1β,IL-6含量测定及其意义[J].第四军医大学学报,2004,25(16):1496-1498. 被引量：9
  • 2Jing YANG,Hua-dong WANG,Da-xiang LU,Yan-ping WANG,Ren-bin QI,Jing LI,Fei LI,Chu-jie LI.Effects of neutral sulfate berberine on LPS-induced cardiomyocyte TNF-(αsecretion,abnormal calcium cycling,and cardiac dysfunction in rats[J].Acta Pharmacologica Sinica,2006,27(2):173-178. 被引量：18
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  • 9Lee SY,Lee JW,Lee H,Yoo HS,Yun YP,Oh KW,et al.Inhibitory effect of green tea extract on beta-amyloid-induced PC12 cell death by inhibition of the activation of NF-kappaB and ERK/p38 MAP kinase pathway through antioxidant mechanisms.Brain Res Mol Brain Res 2005; 140:45-54.
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共引文献81

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二级引证文献36

中国老年学杂志
2015年 第24期

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